Parkinsonism in a patient with valosin-containing protein gene mutation showing: a case report
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DOI: 10.1007/s00415-017-8467-2
Abstract: The valosin-containing protein (VCP) gene has been identified as being responsible for hereditary inclusion body myopathy (IBM) with Paget’s disease of the bones and frontotemporal dementia (IBMPFD) [1] as well as familial amyotrophic lateral sclerosis… read more here.
Keywords: mutation; muscle; valosin containing; parkinsonism ... See more keywords
Structural insight into mutations at 155 position of valosin containing protein (VCP) linked to inclusion body myopathy with Paget disease of bone and frontotemporal Dementia
Sign Up to like & getrecommendations! Published in 2021 at "Saudi Journal of Biological Sciences"
DOI: 10.1016/j.sjbs.2021.02.048
Abstract: Mutations in Valosin-containing protein (VCP) have been implicated in the pathology linked to inclusion body myopathy, paget disease of bone and frontotemporal dementia (IBMPFD). VCP is an essential component of AAA-ATPase superfamily involved in various… read more here.
Keywords: protein; valosin containing; protein vcp; vcp ... See more keywords
The valosin‐containing protein is a novel repressor of cardiomyocyte hypertrophy induced by pressure overload
Sign Up to like & getrecommendations! Published in 2017 at "Aging Cell"
DOI: 10.1111/acel.12653
Abstract: Hypertension‐induced left ventricular hypertrophy (LVH) is an independent risk factor for heart failure. Regression of LVH has emerged as a major goal in the treatment of hypertensive patients. Here, we tested our hypothesis that the… read more here.
Keywords: protein; pressure overload; valosin containing; hypertrophy ... See more keywords
Targeting valosin‐containing protein enhances the efficacy of radiation therapy in esophageal squamous cell carcinoma
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DOI: 10.1111/cas.14184
Abstract: Overcoming resistance to radiation is a great challenge in cancer therapy. Here, we highlight that targeting valosin‐containing protein (VCP) improves radiation sensitivity in esophageal squamous cell carcinoma (ESCC) cell lines and show the potential of… read more here.
Keywords: valosin containing; therapy; cell; containing protein ... See more keywords
Genotype‐phenotype study in patients with valosin‐containing protein mutations associated with multisystem proteinopathy
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DOI: 10.1111/cge.13095
Abstract: Mutations in valosin‐containing protein (VCP), an ATPase involved in protein degradation and autophagy, cause VCP disease, a progressive autosomal dominant adult onset multisystem proteinopathy. The goal of this study is to examine if phenotypic differences… read more here.
Keywords: multisystem proteinopathy; valosin containing; containing protein; disease ... See more keywords
Valosin-Containing Protein Stabilizes Mutant p53 to Promote Pancreatic Cancer Growth
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DOI: 10.1158/0008-5472.can-20-3855
Abstract: These findings identify valosin-containing protein (VCP) as a novel regulator of p53-R273H stability and suggest VCP as a potential target for development of pancreatic cancer therapy. Approximately 80% of human pancreatic ductal adenocarcinomas (PDAC) harbor… read more here.
Keywords: containing protein; p53 r273h; valosin containing; p53 ... See more keywords
Comparative Oncology Assessment of a Novel Inhibitor of Valosin-Containing Protein in Tumor-Bearing Dogs
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-22-0167
Abstract: Abstract Pet dogs with naturally occurring cancers play an important role in studies of cancer biology and drug development. We assessed tolerability, efficacy, and pharmacokinetic/pharmacodynamic relationships with a first-in-class small molecule inhibitor of valosin-containing protein… read more here.
Keywords: oncology; inhibitor valosin; valosin containing; tumor bearing ... See more keywords
Valosin Containing Protein as a Specific Biomarker for Predicting the Development of Acute Coronary Syndrome and Its Complication
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.803532
Abstract: Background Acute coronary syndrome (ACS) consists of a range of acute myocardial ischemia-related manifestations. The adverse events of ACS are usually associated with ventricular dysfunction (VD), which could finally develop to heart failure. Currently, there… read more here.
Keywords: coronary syndrome; biomarker; development; complication ... See more keywords
Valosin Containing Protein (VCP): A Multistep Regulator of Autophagy
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DOI: 10.3390/ijms23041939
Abstract: Valosin containing protein (VCP) has emerged as a central protein in the regulation of the protein quality control (PQC) system. VCP mutations are causative of multisystem proteinopathies, which include neurodegenerative diseases (NDs), and share various… read more here.
Keywords: multistep; protein vcp; valosin containing; protein ... See more keywords
CRISPR/Cas9-Mediated Constitutive Loss of VCP (Valosin-Containing Protein) Impairs Proteostasis and Leads to Defective Striated Muscle Structure and Function In Vivo
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DOI: 10.3390/ijms23126722
Abstract: Valosin-containing protein (VCP) acts as a key regulator of cellular protein homeostasis by coordinating protein turnover and quality control. Mutations in VCP lead to (cardio-)myopathy and neurodegenerative diseases such as inclusion body myopathy with Paget’s… read more here.
Keywords: function; containing protein; muscle; valosin containing ... See more keywords
Modulation of valosin-containing protein by Kyoto University Substances (KUS) as a novel therapeutic strategy for ischemic neuronal diseases
Sign Up to like & getrecommendations! Published in 2017 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.213540
Abstract: Retinal ischemia causes several vision-threatening diseases, including diabetic retinopathy, retinal artery occlusion, and retinal vein occlusion. Intracellular adenosine triphosphate (ATP) depletion and subsequent induced endoplasmic reticulum (ER) stress are proposed to be the underlying mechanisms… read more here.
Keywords: valosin containing; kyoto university; strategy; cell ... See more keywords