Pseudo‐Pelger‐Huët neutrophil morphology due to sodium valproate toxicity
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Hematology"
DOI: 10.1002/ajh.26571
Abstract: A 57-year-old woman was referred for investigation of chronic thrombocytopenia prior to elective hip replacement. Her blood count showed haemoglobin concentration 129 g/L, MCV 96 fL, WBC 6.5 (cid:1) 10 9 /L, neutrophils 3.9 (cid:1)… read more here.
Keywords: pseudo pelger; valproate; sodium valproate; neutrophil morphology ... See more keywords
Agmatine protects against sodium valproate–induced hepatic injury in mice via modulation of nuclear factor‐κB/inducible nitric oxide synthetase pathway
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22227
Abstract: Valproate is a widely used drug against epilepsy and several other neurological disorders although it has deleterious hepatotoxic side effects. The current study was designed to test if agmatine as nitric oxide modulator has protective… read more here.
Keywords: valproate; nitric oxide; factor; hepatic injury ... See more keywords
Cross-sectional evaluation of prescription of valproate and other antiepileptic drugs to pregnant women
Sign Up to like & getrecommendations! Published in 2019 at "Acta Neurologica Belgica"
DOI: 10.1007/s13760-019-01231-2
Abstract: Drug counseling is important in women with epilepsy since data about the effects of maternal antiepileptics on the developing fetus are limited. Although pregnant patients on the most teratogenic drugs are treated in accordance to… read more here.
Keywords: cross sectional; valproate; pregnant women; drug ... See more keywords
Enhanced signaling via ERBB3/PI3K plays a compensatory survival role in pancreatic tumor cells exposed to [neratinib + valproate].
Sign Up to like & getrecommendations! Published in 2020 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2020.109525
Abstract: The ERBB1/2/4 inhibitor neratinib causes plasma membrane-associated K-RAS to mislocalize into intracellular vesicles; this effect is enhanced by HDAC inhibitors and the combination of [neratinib + sodium valproate] is now a phase I trial (NCT03919292).… read more here.
Keywords: neratinib valproate; pancreatic tumor; pi3k; valproate ... See more keywords
Effect of acute and chronic exposure to lovastatin on the anticonvulsant action of classical antiepileptic drugs in the mouse maximal electroshock-induced seizure model.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2021.174290
Abstract: Numerous studies indicate neuroprotective activity of statins, commonly used cholesterol lowering drugs in epilepsy and several other neurological diseases. Promising anti-convulsant and neuroprotective effects of statins, attributed to their anti-excitotoxic and anti-inflammatory action were reported… read more here.
Keywords: valproate; lovastatin; effect; antiepileptic drugs ... See more keywords
Repurposing of sodium valproate in colon cancer associated with diabetes mellitus: Role of HDAC inhibition
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2018.05.026
Abstract: Background and purpose: Diabetic patients are at greater risk for colon cancer. Histone deacetylases (HDACs) serve as common target for both. The key objective of the study was to evaluate the effect of sodium valproate… read more here.
Keywords: valproate; sodium valproate; diabetes mellitus; colon cancer ... See more keywords
Valproate used during pregnancy: What should be done?
Sign Up to like & getrecommendations! Published in 2017 at "European Psychiatry"
DOI: 10.1016/j.eurpsy.2017.01.375
Abstract: Background Sodium valproate can cause serious developmental disorders in unborn babies if taken while pregnant, especially in the first trimester. Aim To review recent literature and advice or treatment for women who have or are… read more here.
Keywords: valproate used; pregnancy; valproate; used pregnancy ... See more keywords
Randomized controlled trial of adjunctive Valproate for cognitive remediation in early course schizophrenia.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of psychiatric research"
DOI: 10.1016/j.jpsychires.2019.08.011
Abstract: BACKGROUND Schizophrenia (SZ) is associated with cognitive impairment that contributes to disability, but the cognitive dysfunction is relatively refractory to pharmacologic intervention. Though Valproate augmentation is reported to improve psychopathology among patients with SZ, its… read more here.
Keywords: valproate; cognitive dysfunction; schizophrenia; early course ... See more keywords
Valproate reverses mania-like behaviors in mice via preferential targeting of HDAC2
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Psychiatry"
DOI: 10.1038/s41380-020-00958-2
Abstract: Valproate (VPA) has been used in the treatment of bipolar disorder since the 1990s. However, the therapeutic targets of VPA have remained elusive. Here we employ a preclinical model to identify the therapeutic targets of… read more here.
Keywords: reverses mania; mania like; valproate reverses; valproate ... See more keywords
Effect of valproate and pregabalin on human anxiety-like behaviour in a randomised controlled trial
Sign Up to like & getrecommendations! Published in 2018 at "Translational Psychiatry"
DOI: 10.1038/s41398-018-0206-7
Abstract: Valproate is an anticonvulsant drug with strong preclinical evidence for reducing anxiety behaviour in rodents but no clear clinical evidence. To motivate clinical trials, we here investigate the use of valproate in a translational human… read more here.
Keywords: pregabalin; valproate; anxiety; like behaviour ... See more keywords
Experience with Low-Dose Sodium Valproate in Idiopathic Generalized Epilepsy Patients: A Long-Term Follow-Up Study on Selective Cohort from North India
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neurosciences in Rural Practice"
DOI: 10.1055/s-0040-1718853
Abstract: Background Idiopathic generalized epilepsy (IGE) is found in 20 to 30% of all patients presenting with seizures. Most of the patients require lifelong drug treatment. Efficacy and tolerability are important issues while selecting the most… read more here.
Keywords: idiopathic generalized; low dose; valproate; dose valproate ... See more keywords