Methodological Insights for Randomized Clinical Trials of Retinitis Pigmentosa: Lessons Learned From a Trial of Valproic Acid.
Sign Up to like & getrecommendations! Published in 2018 at "JAMA ophthalmology"
DOI: 10.1001/jamaophthalmol.2018.1167
Abstract: Retinitis pigmentosa (RP) is a genetically heterogeneous group of photoreceptor degenerations for which no treatments exist. In this issue of JAMA Ophthalmology, Birch and colleagues1 report on the repurposing of oral valproic acid as a… read more here.
Keywords: trial; ophthalmology; study; valproic acid ... See more keywords
Developmental administration of valproic acid alters DNA methylation and maternal behavior.
Sign Up to like & getrecommendations! Published in 2022 at "Developmental psychobiology"
DOI: 10.1002/dev.22231
Abstract: Exposure to adversity in early development has powerful and potentially lasting consequences on behavior. Previous work in our laboratory using female Long-Evans rats has demonstrated that exposure to early-life maltreatment manifests into alterations in dam… read more here.
Keywords: administration valproic; methylation; dna methylation; maltreatment ... See more keywords
Changes of cerebellar cortex in a valproic acid‐induced rat model of autism
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Developmental Neuroscience"
DOI: 10.1002/jdn.10213
Abstract: In this study, 32 male Sprague–Dawley rats (8 for each group) were used in total to examine the effects of valproic acid on rat cerebellum. It was determined that the experimental group received valproic acid… read more here.
Keywords: experimental groups; changes cerebellar; group; numerical density ... See more keywords
A simple and easy non-derivatization gas chromatography-mass spectrometry method for simultaneous quantification of valproic acid, gabapentin, pregabalin, and vigabatrin in human plasma.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of separation science"
DOI: 10.1002/jssc.202200622
Abstract: Immunoassays are currently not available in commercial kits for the quantification of valproic acid, vigabatrin, pregabalin, and gabapentin, which also cannot suffer the limitations of interferences of substances with similar structures. Chromatography is a good… read more here.
Keywords: gas chromatography; chromatography mass; mass spectrometry; plasma ... See more keywords
Subtherapeutic valproic acid plasma concentrations under concomitant dipyrone therapy in an epilepsy patient—a case report
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Clinical Pharmacology"
DOI: 10.1007/s00228-018-2417-5
Abstract: Valproic acid (VPA) is used as a broad anticonvulsant in the treatment of general and focal epilepsy and as maintenance therapy in bipolar disorder [1, 2]. Its effects are mediated by a blockage of voltage-gated… read more here.
Keywords: vpa; valproic acid; pcvpa; therapy ... See more keywords
Population pharmacokinetics of unbound valproic acid in pediatric epilepsy patients in China: a protein binding model.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of clinical pharmacology"
DOI: 10.1007/s00228-020-03080-y
Abstract: PURPOSE The purpose of this study was to establish a protein binding model of unbound valproic acid (VPA) based on Chinese pediatric patients with epilepsy and provide a reference for clinical medication. METHODS A total… read more here.
Keywords: protein binding; valproic acid; model; binding model ... See more keywords
Evaluation of serum levels of asprosin and other metabolic profiles in patients with idiopathic tonic-clonic generalized epilepsy on treatment with valproic acid.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of clinical pharmacology"
DOI: 10.1007/s00228-022-03279-1
Abstract: BACKGROUND This cross-sectional research was undertaken to determine the serum levels of asprosin, a novel white adipose tissue-derived glucogenic adipokine, in epileptic patients on valproic acid treatment. METHODS Sixty-six patients diagnosed with idiopathic tonic-clonic generalized… read more here.
Keywords: levels asprosin; insulin; treatment; serum ... See more keywords
Valproic Acid in Women and Girls of Childbearing Age
Sign Up to like & getrecommendations! Published in 2017 at "Current Psychiatry Reports"
DOI: 10.1007/s11920-017-0809-3
Abstract: Purpose of ReviewThe aim of this paper is to evaluate recent literature on valproic acid (VPA) in women and girls of childbearing age and to emphasize new findings.Recent FindingsRecent research confirms VPAs teratogenicity and risk… read more here.
Keywords: childbearing age; women girls; valproic acid; girls childbearing ... See more keywords
Valproic Acid Promotes Survival of Facial Motor Neurons in Adult Rats After Facial Nerve Transection: a Pilot Study
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-018-1051-0
Abstract: Valproic acid (VPA), a medication primarily used to treat epilepsy and bipolar disorder, has been applied to the repair of central and peripheral nervous system injury. The present study investigated the effect of VPA on… read more here.
Keywords: survival facial; transection; group; valproic acid ... See more keywords
Molecularly imprinted based solid phase microextraction method for monitoring valproic acid in human serum and pharmaceutical formulations
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the Iranian Chemical Society"
DOI: 10.1007/s13738-018-1551-4
Abstract: In this paper, a straightforward method is presented to detect valproic acid after its microextraction. Molecularly imprinted polymer fiber was used in conjunction with chromatography-flame ionization to achieve this goal. A narrow bore silica capillary… read more here.
Keywords: method; valproic acid; human serum; valproic ... See more keywords
Valproic Acid Induced Neurotoxicological Manifestations and its Mitigation by Melatonin in Rat Brain Synaptosomes.
Sign Up to like & getrecommendations! Published in 2018 at "Archives of medical research"
DOI: 10.1016/j.arcmed.2019.01.004
Abstract: BACKGROUND AND AIMS A short branched chain fatty acid, valproic acid (VPA), has been used worldwide for decades in the intervention of seizure disorders, neuropathic pain and migraine. However, several adverse effects of VPA have… read more here.
Keywords: melatonin; rat brain; vpa; valproic acid ... See more keywords