Effect of Sacubitril/Valsartan vs Valsartan on Left Atrial Volume in Patients With Pre–Heart Failure With Preserved Ejection Fraction
Sign Up to like & getrecommendations! Published in 2023 at "JAMA Cardiology"
DOI: 10.1001/jamacardio.2023.0065
Abstract: Key Points Question Can neprilysin inhibition improve markers of cardiovascular structure and function in patients with pre–heart failure with preserved ejection fraction? Findings In this randomized clinical trial of 250 asymptomatic patients, sacubitril/valsartan vs valsartan… read more here.
Keywords: heart failure; preserved ejection; pre heart; failure preserved ... See more keywords
Five Years of Sacubitril/Valsartan—a Safety Analysis of Randomized Clinical Trials and Real-World Pharmacovigilance
Sign Up to like & getrecommendations! Published in 2021 at "Cardiovascular Drugs and Therapy"
DOI: 10.1007/s10557-021-07210-1
Abstract: In PARADIGM-HF, sacubitril/valsartan showed a significant reduction in mortality and hospitalization for patients with heart failure with reduced ejection fraction. Despite proven efficacy, sacubitril/valsartan has moderate uptake in clinical practice. This study explores the safety… read more here.
Keywords: real world; valsartan; sacubitril valsartan; analysis ... See more keywords
MOF Capacitates Cyclodextrin to Mega-Load Mode for High-Efficient Delivery of Valsartan
Sign Up to like & getrecommendations! Published in 2019 at "Pharmaceutical Research"
DOI: 10.1007/s11095-019-2650-3
Abstract: PurposeTo investigate the mechanism of enhancing solubility and bioavailability of water-insoluble drug, valsartan (VAL), with being mega-loaded by cyclodextrin metal organic framework (CD-MOF).MethodsVAL was successfully mega-loaded into CD-MOF by magnetic agitation of VAL in ethanolic solution. Characterizations… read more here.
Keywords: valsartan; mof; val; delivery ... See more keywords
Rationale and design of the PRAETORIAN-COVID trial: A double-blind, placebo-controlled randomized clinical trial with valsartan for PRevention of Acute rEspiraTORy dIstress syndrome in hospitAlized patieNts with SARS-COV-2 Infection Disease
Sign Up to like & getrecommendations! Published in 2020 at "American Heart Journal"
DOI: 10.1016/j.ahj.2020.05.010
Abstract: Abstract Background There is much debate on the use of angiotensin receptor blockers (ARBs) in SARS-CoV-2 infected patients. While it has been suggested that ARBs might lead to a higher susceptibility and severity of SARS-CoV-2… read more here.
Keywords: trial; valsartan; covid trial; praetorian covid ... See more keywords
Clinical Effectiveness of Sacubitril/valsartan among Patients Hospitalized for Heart Failure with Reduced Ejection Fraction
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cardiac Failure"
DOI: 10.1016/j.cardfail.2019.11.003
Abstract: Background Sacubitril/valsartan has been highly efficacious in randomized clinical trials of patients with HFrEF. However, the effectiveness of sacubitril/valsartan in routine US clinical practice is unclear. Methods This study included patients age ≥65 years who… read more here.
Keywords: hospitalization; valsartan; sacubitril valsartan; effectiveness sacubitril ... See more keywords
National Trends in the Use of Sacubitril/Valsartan.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cardiac failure"
DOI: 10.1016/j.cardfail.2021.05.015
Abstract: BACKGROUND Better understanding of recent sacubitril/valsartan prescription patterns may help identify factors that influence its use. The aim of the study was to characterize sacubitril/valsartan use and dosage patterns nationally. METHODS AND RESULTS We conducted… read more here.
Keywords: use sacubitril; valsartan; sacubitril valsartan; target strength ... See more keywords
GW29-e1408 Antioxidant effects of Naoxintong, estradiol and valsartan in ovariectomized mice treated by angiotensin II
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2018.08.465
Abstract: To Investigate the effects of Naoxintong capsule (NXT), valsartan and estradiol(E2) on oxidative stress in ovariectomized(OVX) female mice treated with angII,and its correlation with blood pressure. Female mice randomly divided into 10 groups: Blank, Blank+Oil,… read more here.
Keywords: valsartan; e1408 antioxidant; effects naoxintong; mice treated ... See more keywords
Application of an LC–MS/MS method for the analysis of amlodipine, valsartan and hydrochlorothiazide in polypill for a bioequivalence study
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pharmaceutical Analysis"
DOI: 10.1016/j.jpha.2017.06.001
Abstract: A sensitive and selective method has been proposed for the simultaneous determination of amlodipine (AML), valsartan (VAL) and hydrochlorothiazide (HCTZ) in human plasma by liquid chromatography–tandem mass spectrometry (LC–MS/MS). The analytes and their deuterated analogs… read more here.
Keywords: valsartan; val; method; hctz ... See more keywords
Comparative degradation of two highly consumed antihypertensives in water by sonochemical process. Determination of the reaction zone, primary degradation products and theoretical calculations on the oxidative process.
Sign Up to like & getrecommendations! Published in 2019 at "Ultrasonics sonochemistry"
DOI: 10.1016/j.ultsonch.2019.104635
Abstract: This work compares the sonochemical degradation of losartan and valsartan (antihypertensives) in water. Initially, the suitable operational conditions of ultrasonic power density and frequency were established. Under such conditions, losartan was eliminated in a higher… read more here.
Keywords: theoretical calculations; process; degradation; antihypertensives water ... See more keywords
Brain-targeted delivery of Valsartan using solid lipid nanoparticles labeled with Rhodamine B; a promising technique for mitigating the negative effects of stroke
Sign Up to like & getrecommendations! Published in 2023 at "Drug Delivery"
DOI: 10.1080/10717544.2023.2179127
Abstract: Abstract The brain is a vital organ that is protected from the general circulation and is distinguished by the presence of a relatively impermeable blood brain barrier (BBB). Blood brain barrier prevents the entry of… read more here.
Keywords: solid lipid; brain; delivery; effects stroke ... See more keywords
Cardiovascular biomarkers in patients with acute decompensated heart failure randomized to sacubitril-valsartan or enalapril in the PIONEER-HF trial
Sign Up to like & getrecommendations! Published in 2019 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehz240
Abstract: Abstract Aims Circulating high-sensitivity cardiac troponin (hsTn) and soluble ST2 (sST2) reflect myocardial stress in patients with heart failure (HF). Production of cyclic guanosine 3′5′ monophosphate (cGMP) in response to activation of natriuretic peptide receptors… read more here.
Keywords: heart; valsartan; sacubitril valsartan; valsartan enalapril ... See more keywords