Atractylodin targets GLA to regulate D‐mannose metabolism to inhibit osteogenic differentiation of human valve interstitial cells and ameliorate aortic valve calcification
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7628
Abstract: Atractylodin (ATL) has been reported to exert anti‐inflammatory effects. Osteogenic changes induced by inflammation in valve interstitial cells (VICs) play a key role in the development of calcified aortic valve disease (CAVD). This study aimed… read more here.
Keywords: aortic valve; calcification; atl; valve calcification ... See more keywords
Visual ordinal grading of aortic valve calcification on routine non-gated chest CT predicts prognosis and alters management
Sign Up to like & getrecommendations! Published in 2025 at "European Radiology"
DOI: 10.1007/s00330-025-11553-w
Abstract: BSCI/BSTI guidelines recommend reporting aortic valve calcification (AVC) on all chest CTs regardless of indication. We assessed AVC frequency, severity, and association with aortic stenosis (AS) on echocardiography and its prognostic implications. Retrospective, single-centre analysis… read more here.
Keywords: age; cause mortality; aortic valve; valve calcification ... See more keywords
Cellular Mechanisms of Aortic Valve Calcification
Sign Up to like & getrecommendations! Published in 2018 at "Bulletin of Experimental Biology and Medicine"
DOI: 10.1007/s10517-018-3992-2
Abstract: Comparative in vitro study examined the osteogenic potential of interstitial cells of aortic valve obtained from the patients with aortic stenosis and from control recipients of orthotopic heart transplantation with intact aortic valve. The osteogenic… read more here.
Keywords: control; aortic stenosis; valve calcification; aortic valve ... See more keywords
Aortic Valve Calcification Score in Patients with Arterial Hypertension Environmentally Exposed to Tobacco Smoke
Sign Up to like & getrecommendations! Published in 2021 at "Cardiovascular Toxicology"
DOI: 10.1007/s12012-021-09677-8
Abstract: The objective of our study was to determine the relationship between exposure to environmental tobacco smoke (ETS) and the value of the aortic valve calcification score (AVCS) in people suffering from arterial hypertension (AH). 107… read more here.
Keywords: valve calcification; aortic valve; exposure; value ... See more keywords
Andrographolide ameliorates aortic valve calcification by regulation of lipid biosynthesis and glycerolipid metabolism targeting MGLL expression in vitro and in vivo.
Sign Up to like & getrecommendations! Published in 2021 at "Cell calcium"
DOI: 10.1016/j.ceca.2021.102495
Abstract: Calcific aortic valve disease (CAVD) is caused by the initiation of the thickening and calcification of valve leaflets by valve interstitial cells (VICs). Cell metabolic changes during the CAVD process are a new field of… read more here.
Keywords: aortic valve; calcification; expression; glycerolipid metabolism ... See more keywords
STRONG CORRELATION BETWEEN AORTIC VALVE CALCIFICATION SCORE BY CARDIAC COMPUTED TOMOGRAPHY AND TOTAL VALVE CALCIUM IN PATIENTS WITH SEVERE AORTIC VALVE STENOSIS
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American College of Cardiology"
DOI: 10.1016/s0735-1097(18)32526-9
Abstract: Aortic valve calcification score (AVC) estimated by cardiac Computed Tomography (CT) can be used in the evaluation of aortic valve stenosis (AS) but few studies have investigated the correlation with total calcium weight in the… read more here.
Keywords: computed tomography; calcification score; aortic valve; valve calcification ... See more keywords
The association of peritoneal dialysis and hemodialysis on mitral and aortic valve calcification associated mortality: a meta-analysis
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-55326-9
Abstract: Cardiac valve calcification (CVC), characterized by the accumulation of calcium in the heart valves, is highly prevalent among patients undergoing dialysis. This meta-analysis aimed to provide an updated summary of recent studies on the prognostic… read more here.
Keywords: mortality; meta analysis; dialysis; valve calcification ... See more keywords
Elucidating common biomarkers and pathways of osteoporosis and aortic valve calcification: insights into new therapeutic targets
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-78707-6
Abstract: Background: Osteoporosis and aortic valve calcification, prevalent in the elderly, have unclear common mechanisms. This study aims to uncover them through bioinformatics analysis. Methods: Microarray data from GEO was analyzed for osteoporosis and aortic valve… read more here.
Keywords: elucidating common; valve calcification; aortic valve; osteoporosis aortic ... See more keywords
Association of Matrix Metalloproteinase-2 (MMP-2) and MMP-9 Promoter Variants, Their Serum Levels, and Activities with Aortic Valve Calcification (AVC) in a Population from Western Iran
Sign Up to like & getrecommendations! Published in 2024 at "Genetic Testing and Molecular Biomarkers"
DOI: 10.1089/gtmb.2023.0370
Abstract: Background: Matrix metalloproteinase (MMP) enzyme gene polymorphisms MMP-2-1575G/A and MMP-9-1562C/T promoter polymorphism, their serum levels, and activity are associated with aortic valve calcification (AVC). Materials and Methods: The synergistic link between the risk of AVC… read more here.
Keywords: mmp; mmp mmp; promoter; valve calcification ... See more keywords
Oxidized LDL-induced FOXS1 mediates cholesterol transport dysfunction and inflammasome activation to drive aortic valve calcification
Sign Up to like & getrecommendations! Published in 2025 at "Cardiovascular Research"
DOI: 10.1093/cvr/cvaf159
Abstract: Abstract Aims Calcific aortic valve disease (CAVD) is becoming more prevalent with the population ageing; however, there is currently no medical therapy available. During early lipid deposition, low-density lipoprotein (LDL) mediates chronic inflammation and accelerates… read more here.
Keywords: valve; cholesterol transport; foxs1; aortic valve ... See more keywords
Association of aortic valve calcification and vitamin K antagonist treatment.
Sign Up to like & getrecommendations! Published in 2020 at "European heart journal cardiovascular Imaging"
DOI: 10.1093/ehjci/jeaa065
Abstract: AIMS Vitamin K antagonists (VKAs) are suspected of causing aortic valve calcification (AVC). The objective of this study was to clarify whether patients undergoing VKA treatment have increased AVC scores compared to patients treated with… read more here.
Keywords: avc score; treatment; aortic valve; association ... See more keywords