Atractylodin targets GLA to regulate D‐mannose metabolism to inhibit osteogenic differentiation of human valve interstitial cells and ameliorate aortic valve calcification
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7628
Abstract: Atractylodin (ATL) has been reported to exert anti‐inflammatory effects. Osteogenic changes induced by inflammation in valve interstitial cells (VICs) play a key role in the development of calcified aortic valve disease (CAVD). This study aimed… read more here.
Keywords: aortic valve; calcification; atl; valve calcification ... See more keywords
Cellular Mechanisms of Aortic Valve Calcification
Sign Up to like & getrecommendations! Published in 2018 at "Bulletin of Experimental Biology and Medicine"
DOI: 10.1007/s10517-018-3992-2
Abstract: Comparative in vitro study examined the osteogenic potential of interstitial cells of aortic valve obtained from the patients with aortic stenosis and from control recipients of orthotopic heart transplantation with intact aortic valve. The osteogenic… read more here.
Keywords: control; aortic stenosis; valve calcification; aortic valve ... See more keywords
Aortic Valve Calcification Score in Patients with Arterial Hypertension Environmentally Exposed to Tobacco Smoke
Sign Up to like & getrecommendations! Published in 2021 at "Cardiovascular Toxicology"
DOI: 10.1007/s12012-021-09677-8
Abstract: The objective of our study was to determine the relationship between exposure to environmental tobacco smoke (ETS) and the value of the aortic valve calcification score (AVCS) in people suffering from arterial hypertension (AH). 107… read more here.
Keywords: valve calcification; aortic valve; exposure; value ... See more keywords
Andrographolide ameliorates aortic valve calcification by regulation of lipid biosynthesis and glycerolipid metabolism targeting MGLL expression in vitro and in vivo.
Sign Up to like & getrecommendations! Published in 2021 at "Cell calcium"
DOI: 10.1016/j.ceca.2021.102495
Abstract: Calcific aortic valve disease (CAVD) is caused by the initiation of the thickening and calcification of valve leaflets by valve interstitial cells (VICs). Cell metabolic changes during the CAVD process are a new field of… read more here.
Keywords: aortic valve; calcification; expression; glycerolipid metabolism ... See more keywords
STRONG CORRELATION BETWEEN AORTIC VALVE CALCIFICATION SCORE BY CARDIAC COMPUTED TOMOGRAPHY AND TOTAL VALVE CALCIUM IN PATIENTS WITH SEVERE AORTIC VALVE STENOSIS
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American College of Cardiology"
DOI: 10.1016/s0735-1097(18)32526-9
Abstract: Aortic valve calcification score (AVC) estimated by cardiac Computed Tomography (CT) can be used in the evaluation of aortic valve stenosis (AS) but few studies have investigated the correlation with total calcium weight in the… read more here.
Keywords: computed tomography; calcification score; aortic valve; valve calcification ... See more keywords
Association of aortic valve calcification and vitamin K antagonist treatment.
Sign Up to like & getrecommendations! Published in 2020 at "European heart journal cardiovascular Imaging"
DOI: 10.1093/ehjci/jeaa065
Abstract: AIMS Vitamin K antagonists (VKAs) are suspected of causing aortic valve calcification (AVC). The objective of this study was to clarify whether patients undergoing VKA treatment have increased AVC scores compared to patients treated with… read more here.
Keywords: avc score; treatment; aortic valve; association ... See more keywords
Endothelial cell-derived tetrahydrobiopterin prevents aortic valve calcification.
Sign Up to like & getrecommendations! Published in 2022 at "European heart journal"
DOI: 10.1093/eurheartj/ehac037
Abstract: AIMS Tetrahydrobiopterin (BH4) is a critical determinant of the biological function of endothelial nitric oxide synthase. The present study was to investigate the role of valvular endothelial cell (VEC)-derived BH4 in aortic valve calcification. METHODS… read more here.
Keywords: valve calcification; aortic valve; endothelial cell;
Aortic valve calcification: a bone of contention
Sign Up to like & getrecommendations! Published in 2017 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehw071
Abstract: Pathologists have known for centuries that calcific deposits formed in vascular tissues such as the aortic valve. Calcific deposits are hard like bone and have often been described as such. In his ‘History of Animals’,… read more here.
Keywords: aortic valve; valve calcification; bone; calcification bone ... See more keywords
MO907ASSOCIATION OF ADIPOSITY AND SARCOPENIA WITH CARDIAC VALVE CALCIFICATION IN PATIENTS ON MAINTENANCE HEMODIALYSIS. A CROSS-SECTIONAL STUDY
Sign Up to like & getrecommendations! Published in 2021 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfab102.008
Abstract: Cardiac valve calcification (CVC) is a common disorder in patients with end stage kidney disease (ESKD) and is a predictor of cardiovascular disease and all-cause mortality. Several risk factors are related to CVC in patients… read more here.
Keywords: valve calcification; valve; hemodialysis; cardiac valve ... See more keywords
Association between Aortic Valve Calcification Progression and Coronary Atherosclerotic Plaque Volume Progression in the PARADIGM Registry.
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DOI: 10.1148/radiol.2021202630
Abstract: Background Aortic valve calcification (AVC) is a key feature of aortic stenosis, and patients with aortic stenosis often have coronary -artery disease. Therefore, proving the association between the progression of AVC and coronary atherosclerosis could… read more here.
Keywords: progression; valve calcification; aortic valve; plaque volume ... See more keywords
Network-Guided Multiomic Mapping of Aortic Valve Calcification.
Sign Up to like & getrecommendations! Published in 2023 at "Arteriosclerosis, thrombosis, and vascular biology"
DOI: 10.1161/atvbaha.122.318334
Abstract: Despite devastating clinical sequelae of calcific aortic valve disease that range from left ventricular remodeling to arrhythmias, heart failure, and early death, the molecular insights into disease initiation and progression are limited and pharmacotherapies remain… read more here.
Keywords: network; aortic valve; valve; valve calcification ... See more keywords