Crosstalk between myofibroblasts and macrophages: A regulative factor of valvular fibrosis in calcific aortic valve disease
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11980
Abstract: Inflammation and fibrosis are highly correlated with the progression of calcific aortic valve disease (CAVD). As one of the differentiated forms of valvular interstitial cells, myofibroblasts play a critical role in CAVD's development as do… read more here.
Keywords: aortic valve; myofibroblasts macrophages; valve disease; crosstalk myofibroblasts ... See more keywords
Heart valve disease, left ventricular hypertrophy, and heart failure: a lifelong relationship and continuing clinical responsibility
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Heart Failure"
DOI: 10.1002/ejhf.2373
Abstract: It is abundantly clear that clinical outcomes after interventions for left-sided heart valve disease are related to preoperative left ventricular hypertrophy (LVH) and myocardial fibrosis. The timing of treatment is influenced by the detection of… read more here.
Keywords: valve disease; heart failure; left ventricular; heart ... See more keywords
Identification of atrial fibrillation‐associated lncRNAs in atria from patients with rheumatic mitral valve disease
Sign Up to like & getrecommendations! Published in 2019 at "Microscopy Research and Technique"
DOI: 10.1002/jemt.23261
Abstract: We analysed lncRNA expression profiles in atrial samples from patients with rheumatic mitral valve disease (RMVD) to identify the potential differences in atrial fibrillation (AF)‐associated lncRNAs between RMVD patients with AF and sinus rhythm (SR). read more here.
Keywords: atrial fibrillation; patients rheumatic; rheumatic mitral; mitral valve ... See more keywords
Atrioventricular valve disease: challenges and achievements in percutaneous treatment
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Research in Cardiology"
DOI: 10.1007/s00392-018-1303-6
Abstract: Percutaneous treatment of atrioventricular (AV) valve disease has long been restricted to therapy of mitral stenosis, and was only lately expanded to mitral regurgitation. 15 years ago the MitraClip edge to edge repair was first applied… read more here.
Keywords: valve disease; percutaneous treatment; valve; atrioventricular valve ... See more keywords
Identification of miR-143 as a Major Contributor for Human Stenotic Aortic Valve Disease
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cardiovascular Translational Research"
DOI: 10.1007/s12265-019-09880-7
Abstract: Calcification of aortic valves leads to aortic stenosis mainly in elderly individuals, but the underlying molecular mechanisms are still not understood. Here, we studied microRNA (miR, miRNA) expression and function in healthy and stenotic human… read more here.
Keywords: mir 143; aortic valves; stenotic aortic; disease ... See more keywords
Tumor necrosis factor alpha and interleukin 1 beta suppress myofibroblast activation via nuclear factor kappa B signaling in 3D-cultured mitral valve interstitial cells.
Sign Up to like & getrecommendations! Published in 2021 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2021.03.075
Abstract: Mitral valve disease is a major cause of cardiovascular morbidity throughout the world. Many different mitral valve pathologies feature fibrotic remodeling, often accompanied by an inflammatory state. Mitral valve fibrosis is mediated by valvular interstitial… read more here.
Keywords: interstitial cells; mitral valve; myofibroblast; valve disease ... See more keywords
Exploring potential genes and pathways related to calcific aortic valve disease.
Sign Up to like & getrecommendations! Published in 2021 at "Gene"
DOI: 10.1016/j.gene.2021.145987
Abstract: Calcific aortic valve disease (CAVD) is currently the most prevalent valvular disease. However, the pathological mechanism of CAVD has not yet been fully elucidated, and no drugs can delay or halt the progression of CAVD.… read more here.
Keywords: aortic valve; disease; calcific aortic; valve disease ... See more keywords
Aortic Valve Disease Is Not a Monogenetic Disorder
Sign Up to like & getrecommendations! Published in 2017 at "JACC: Basic to Translational Science"
DOI: 10.1016/j.jacbts.2017.09.003
Abstract: The recent publication in JACC: Basic to Translational Science by Torzewski et al. [(1)][1] highlights a rapidly evolving mechanism in the development of calcific aortic valve disease (CAVD), which includes the role of lysophosphatidic acid (LPA)… read more here.
Keywords: valve disease; disease monogenetic; aortic valve; monogenetic disorder ... See more keywords
TCT-458 In-Hospital Outcomes of Transcatheter Mitral Valve Repair in Rheumatic Mitral Valve Disease
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2019.08.548
Abstract: There is a paucity of data on the off-label use of transcatheter mitral valve repair (TMVR) in patients with rheumatic mitral valve disease (RMV). The authors queried the NIS database (2012 to 2016) to identify… read more here.
Keywords: transcatheter mitral; valve repair; rheumatic mitral; mitral valve ... See more keywords
Serotonin contribution to cardiac valve degeneration: new insights for novel therapies?
Sign Up to like & getrecommendations! Published in 2019 at "Pharmacological research"
DOI: 10.1016/j.phrs.2018.09.009
Abstract: Heart valve disease (HVD) is a complex entity made by different pathological processes that ultimately lead to the abnormal structure and disorganization of extracellular matrix proteins resulting to dysfunction of the leaflets. At its final… read more here.
Keywords: heart; serotonin; disease; valve disease ... See more keywords
GENDER DIFFERENCES IN THE ETIOLOGY OF MITRAL VALVE DISEASE
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American College of Cardiology"
DOI: 10.1016/s0735-1097(17)35361-5
Abstract: Background: Women historically have poorer outcomes following mitral valve surgery. This study sought to define gender differences in the etiology of valve disease for patients undergoing mitral valve surgery. Methods: We retrospectively analyzed primary mitral… read more here.
Keywords: gender differences; differences etiology; etiology; mitral valve ... See more keywords