Berberine inhibits osteogenic differentiation of aortic valve interstitial cells by interfering Smad1/5/8 and NF-κB pathways.
Sign Up to like & getrecommendations! Published in 2022 at "Vascular pharmacology"
DOI: 10.1016/j.vph.2022.106986
Abstract: AIMS Calcified aortic valve disease (CAVD) is a cardiovascular disease with increasing morbidity and mortality. The pathogenetic cellular mechanism is the phenotype transition of aortic valve interstitial cells (VICs). Here, we explored the effect of… read more here.
Keywords: osteogenic differentiation; aortic valve; valve interstitial; smad1 ... See more keywords
Label-free metabolic biomarkers for assessing valve interstitial cell calcific progression
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-66960-4
Abstract: Calcific aortic valve disease (CAVD) is the most common form of valve disease where the only available treatment strategy is surgical valve replacement. Technologies for the early detection of CAVD would benefit the development of… read more here.
Keywords: redox ratio; valve interstitial; optical redox; fractal dimension ... See more keywords
Estimation of aortic valve interstitial cell-induced 3D remodeling of poly(ethylene glycol) hydrogel environments using an inverse finite element approach.
Sign Up to like & getrecommendations! Published in 2023 at "Acta biomaterialia"
DOI: 10.2139/ssrn.4186612
Abstract: Aortic valve interstitial cells (AVICs) reside within the leaflet tissues of the aortic valve and maintain and remodel its extracellular matrix components. Part of this process is a result of AVIC contractility brought about by… read more here.
Keywords: aortic valve; hydrogel; valve; microscopy ... See more keywords
Identifying molecular and functional similarities and differences between human primary cardiac valve interstitial cells and ventricular fibroblasts
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2023.1102487
Abstract: Introduction: Fibroblasts are mesenchymal cells that predominantly produce and maintain the extracellular matrix (ECM) and are critical mediators of injury response. In the heart, valve interstitial cells (VICs) are a population of fibroblasts responsible for… read more here.
Keywords: identifying molecular; cardiac fibroblasts; similarities differences; human primary ... See more keywords
Disturbing effect of cepharanthine on valve interstitial cells calcification via regulating glycolytic metabolism pathways
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1070922
Abstract: Osteogenic differentiation of valve interstitial cells (VICs) directly leads to aortic valve calcification, which is a common cardiovascular disease caused by inflammation and metabolic disorder. There is still no ideal drug for its treatment and… read more here.
Keywords: calcification; regulating glycolytic; kcal mol; valve interstitial ... See more keywords
Purinergic Receptor P2Y2 Stimulation Averts Aortic Valve Interstitial Cell Calcification and Myofibroblastic Activation
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10020457
Abstract: Rationale—Calcific aortic valve stenosis (CAVS) is a pathological condition of the aortic valve with a prevalence of 3% in the general population. It is characterized by massive rearrangement of the extracellular matrix, mostly due to… read more here.
Keywords: aortic valve; calcification; calcification myofibroblastic; valve interstitial ... See more keywords
Protective Effects of Fucoxanthin on Hydrogen Peroxide-Induced Calcification of Heart Valve Interstitial Cells
Sign Up to like & getrecommendations! Published in 2021 at "Marine Drugs"
DOI: 10.3390/md19060307
Abstract: Cardiovascular diseases such as atherosclerosis and aortic valve sclerosis involve inflammatory reactions triggered by various stimuli, causing increased oxidative stress. This increased oxidative stress causes damage to the heart cells, with subsequent cell apoptosis or… read more here.
Keywords: heart; interstitial cells; valve interstitial; heart valve ... See more keywords
Carbon Nanotubes Substrates Alleviate Pro-Calcific Evolution in Porcine Valve Interstitial Cells
Sign Up to like & getrecommendations! Published in 2021 at "Nanomaterials"
DOI: 10.3390/nano11102724
Abstract: The quest for surfaces able to interface cells and modulate their functionality has raised, in recent years, the development of biomaterials endowed with nanocues capable of mimicking the natural extracellular matrix (ECM), especially for tissue… read more here.
Keywords: interstitial cells; carbon nanotubes; valve interstitial; morphology ... See more keywords
High mobility group box 1 induces calcification of aortic valve interstitial cells via toll-like receptor 4
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2017.6287
Abstract: Chronic inflammation and the calcification of aortic valve interstitial cells (AVICs) are the primary etiologies of calcific aortic valve disease (CAVD). However, the underlying mechanism remains to be elucidated. The present study investigated the importance… read more here.
Keywords: interstitial cells; aortic valve; calcification; valve interstitial ... See more keywords