Substrate Chemistry and Morphology Influence the Valvular Interstitial Cells Mechanobiology
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.2331
Abstract: Calcific Aortic Valve Disease (CAVD) is the most common form of valve disease in the Western world and represents a major healthcare burden. The primary driver for valvular calcification is the differentiation of valvular interstitial… read more here.
Keywords: valvular interstitial; interstitial cells; microscopy; chemistry ... See more keywords
Mechanical strain induces a pro-fibrotic phenotype in human mitral valvular interstitial cells through RhoC/ROCK/MRTF-A and Erk1/2 signaling pathways.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2019.08.008
Abstract: The mitral valve is a complex multilayered structure populated by fibroblast-like cells, valvular interstitial cells (VIC) which are embedded in an extracellular matrix (ECM) scaffold and are submitted to the mechanical deformations affecting valve at… read more here.
Keywords: mrtf; mechanical strain; valvular interstitial; rhoc rock ... See more keywords
Role of vitamin K2 and vitamin K cycle enzymes in aortic valvular interstitial cell calcification
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DOI: 10.1093/eurheartj/ehae666.3798
Abstract: Calcific aortic valve disease (CAVD) is the most common valve disease. Currently, there is no medical treatment available for CAVD. Vitamin K antagonists promote CAVD while population-based studies suggest that dietary intake of vitamin K… read more here.
Keywords: vitamin; valvular interstitial; culture; role vitamin ... See more keywords
Trpv4 Mechanosensing Mediates Valvular Interstitial Cell Differentiation to Myofibroblast
Sign Up to like & getrecommendations! Published in 2024 at "Physiology"
DOI: 10.1152/physiol.2024.39.s1.1162
Abstract: Aortic valve stenosis (AVS) is a heart disease that gradually worsens, marked by the fibrosis, inflammation, and stiffening of the aortic valve leaflets, which results in obstructed blood flow and increased pressure on the left… read more here.
Keywords: myofibroblast; physiology; valvular interstitial; trpv4 mechanosensing ... See more keywords
Secreted Factors From Proinflammatory Macrophages Promote an Osteoblast-Like Phenotype in Valvular Interstitial Cells
Sign Up to like & getrecommendations! Published in 2020 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.120.315261
Abstract: Supplemental Digital Content is available in the text. Objective: Resident valvular interstitial cells (VICs) activate to myofibroblasts during aortic valve stenosis progression, which further promotes fibrosis or even differentiate into osteoblast-like cells that can lead… read more here.
Keywords: phenotype; osteoblast like; interstitial cells; valvular interstitial ... See more keywords
VCAM-1 Targeted Lipopolyplexes as Vehicles for Efficient Delivery of shRNA-Runx2 to Osteoblast-Differentiated Valvular Interstitial Cells; Implications in Calcific Valve Disease Treatment
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23073824
Abstract: Calcific aortic valve disease (CAVD) is a progressive inflammatory disorder characterized by extracellular matrix remodeling and valvular interstitial cells (VIC) osteodifferentiation leading to valve leaflets calcification and impairment movement. Runx2, the master transcription factor involved… read more here.
Keywords: valvular interstitial; osteoblast differentiated; valve disease; delivery ... See more keywords
Defining the Role of the miR-145—KLF4—αSMA Axis in Mitral Valvular Interstitial Cell Activation in Myxomatous Mitral Valve Prolapse Using the Canine Model
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms25031468
Abstract: Mitral valve prolapse (MVP) is a common valvular disease, affecting 2–3% of the adult human population and is a degenerative condition. A total of 5–10% of the afflicted will develop severe mitral regurgitation, cardiac dysfunction,… read more here.
Keywords: mitral valve; valvular interstitial; valve prolapse; 145 klf4 ... See more keywords
TRPV1 Receptor Identification in Bovine and Canine Mitral Valvular Interstitial Cells
Sign Up to like & getrecommendations! Published in 2021 at "Veterinary Sciences"
DOI: 10.3390/vetsci8090183
Abstract: Myxomatous mitral valve degeneration (MMVD) is the most common acquired cardiac disease in canine species, and valvular interstitial cells (VICs) are considered the main responsible for the development of this pathology. The scientific interest is… read more here.
Keywords: valvular interstitial; interstitial cells; bovine canine; isolation method ... See more keywords