N-(2-Hydroxyethyl)-l-valyl-l-leucine in rat urine as a hydrolytic cleavage product of ethylene oxide adduct with globin
Sign Up to like & getrecommendations! Published in 2019 at "Archives of Toxicology"
DOI: 10.1007/s00204-019-02388-8
Abstract: Ethylene oxide (EO), a genotoxic industrial chemical and sterilant, forms covalent adducts with DNA and also with nucleophilic amino acids in proteins. The adduct with N-terminal valine in globin [N-(2-hydroxyethyl)valine (HEV)] has been used in… read more here.
Keywords: valyl leucine; globin; ethylene oxide; hevl ... See more keywords
N-(2-Hydroxyethyl)-L-valyl-L-leucine: a novel urinary biomarker of ethylene oxide exposure in humans.
Sign Up to like & getrecommendations! Published in 2020 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2020.03.004
Abstract: Ethylene oxide (EO), a carcinogenic chemical used as an industrial intermediate and sterilant, forms covalent adducts with DNA and proteins. The adduct with N-terminal valine [N-(2-hydroxyethyl)-L-valine, HEV] in blood protein globin has been employed as… read more here.
Keywords: valyl leucine; biomarker; ethylene oxide; hevl ... See more keywords
HPLC-ESI-HRMS2 Determination of N-(2-hydroxyethyl)-L-valyl-L-leucine in Human Urine: Method Validation.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of analytical toxicology"
DOI: 10.1093/jat/bkac022
Abstract: Biomonitoring of human exposure to reactive electrophilic chemicals such as ethylene oxide (EO) has been commonly based on determination of adducts with N-terminal valine in blood protein globin but a systematic search has also been… read more here.
Keywords: hevl; validation; valyl leucine; hydroxyethyl valyl ... See more keywords