Structures of ferroportin in complex with its specific inhibitor vamifeport
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.08.29.505642
Abstract: A central regulatory mechanism of iron homeostasis in humans involves ferroportin (FPN), the sole cellular iron exporter, and the peptide hormone hepcidin, which inhibits Fe2+ transport and induces internalization and degradation of FPN. Dysregulation of… read more here.
Keywords: structures ferroportin; iron; fpn; inhibitor vamifeport ... See more keywords
The oral ferroportin inhibitor vamifeport improves hemodynamics in a mouse model of sickle cell disease
Sign Up to like & getrecommendations! Published in 2022 at "Blood"
DOI: 10.1182/blood.2021014716
Abstract: Nyffenegger and colleagues report that blocking ferriportin with vamifeport reduces hemolysis in a murine model of sickle cell disease (SCD). Vamifeport reduces intracellular iron and induces iron-limited hematopoiesis. Since a small decrease in the intracellular… read more here.
Keywords: cell disease; vamifeport; sickle cell; hemodynamics ... See more keywords
Ferroportin inhibitor vamifeport ameliorates ineffective erythropoiesis in a mouse model of β-thalassemia with blood transfusions.
Sign Up to like & getrecommendations! Published in 2023 at "Haematologica"
DOI: 10.3324/haematol.2022.282328
Abstract: β-thalassemia is an inherited anemia characterized by ineffective erythropoiesis. Blood transfusions are required for survival in transfusion-dependent β-thalassemia and are also occasionally needed in patients with non-transfusion-dependent β-thalassemia. Patients with transfusion-dependent β-thalassemia often have elevated… read more here.
Keywords: thalassemia; blood transfusions; ineffective erythropoiesis; vamifeport ... See more keywords