Unconventional secretion of tau by VAMP8 impacts its intra- and extracellular cleavage
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DOI: 10.3389/fcell.2022.912118
Abstract: In Alzheimer’s disease, Tau, a microtubule-associated protein, becomes hyperphosphorylated, detaches from microtubules, and accumulates in the somato-dendritic compartment where it forms insoluble aggregates. Tau also accumulates in the CSF of patients indicating that it is… read more here.
Keywords: cleavage; tau; vamp8; intra extracellular ... See more keywords