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Published in 2017 at "Asian Journal of Organic Chemistry"
DOI: 10.1002/ajoc.201600531
Abstract: A facile, elegant, and operationally simple van Leusen protocol for the synthesis of bicyclic dihydrodibenzo[b,f]imidazo[1,2-d][1,4]thiazepines and dihydrodibenzo[b,f]imidazo[1,2-d][1,4]oxazepines is developed. The reaction proceeds without any catalyst and in high yields to provide bicyclic imidazo-dibenzothia-/oxazepines at room temperature…
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Keywords:
van leusen;
leusen protocol;
facile construction;
construction imidazo ... See more keywords
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Published in 2020 at "Pharmaceuticals"
DOI: 10.3390/ph13030037
Abstract: Imidazole and its derivatives are one of the most vital and universal heterocycles in medicinal chemistry. Owing to their special structural features, these compounds exhibit a widespread spectrum of significant pharmacological or biological activities, and…
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Keywords:
van leusen;
medicinal molecules;
based medicinal;
imidazole based ... See more keywords