New insights into the vancomycin‐induced nephrotoxicity using in vitro metabolomics combined with physiologically based pharmacokinetic modeling
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DOI: 10.1002/jat.3951
Abstract: Vancomycin is a first‐line treatment for invasive infections caused by multidrug‐resistant gram‐positive bacteria. However, vancomycin‐induced nephrotoxicity is an increasing burden, particularly in patients with complex life‐threatening conditions. Vancomycin‐induced nephrotoxicity associated with clinically relevant exposure on… read more here.
Keywords: vancomycin; based pharmacokinetic; induced nephrotoxicity; physiologically based ... See more keywords
Long-Acting Lipoglycopeptides Can Interfere With Vancomycin Therapeutic Drug Monitoring.
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DOI: 10.1002/jcph.1975
Abstract: Oritavancin and dalbavancin are long-acting lipoglycopeptides with activity against susceptible gram-positive bacteria, including methicillin-resistant Staphylococcus aureus. Though similar in structure to traditional glycopeptide antibiotics like vancomycin, these antibiotics have terminal half-lives greater than 10 days,… read more here.
Keywords: vancomycin; long acting; therapeutic drug; acting lipoglycopeptides ... See more keywords
Molecular mechanisms of vancomycin resistance
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DOI: 10.1002/pro.3819
Abstract: Vancomycin and related glycopeptides are drugs of last resort for the treatment of severe infections caused by Gram‐positive bacteria such as Enterococcus species, Staphylococcus aureus, and Clostridium difficile. Vancomycin was long considered immune to resistance… read more here.
Keywords: vancomycin; mechanisms vancomycin; resistance; vancomycin resistance ... See more keywords
Single-nucleotide polymorphisms in a vancomycin-resistant Staphylococcus aureus strain based on whole-genome sequencing
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DOI: 10.1007/s00203-020-01906-y
Abstract: The emergence of vancomycin-resistant Staphylococcus aureus (VRSA) threatens global health. The mechanism of vancomycin resistance of VRSA without vanA gene acquisition was not fully elucidated. Therefore, we aimed to determine the mechanism of vancomycin resistance… read more here.
Keywords: vancomycin; v036 v64; nucleotide polymorphisms; aureus ... See more keywords
Population pharmacokinetic analysis of vancomycin in pediatric continuous renal replacement therapy
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DOI: 10.1007/s00228-019-02664-7
Abstract: Background and objectivesDosing of vancomycin in pediatric patients undergoing continuous venous–venous hemodiafiltration (CVVHDF) is challenging. Characterization of vancomycin pharmacokinetics can assist with dosing and attainment of goal serum concentrations.Design, setting, participants, and measurementsPatients less than… read more here.
Keywords: vancomycin; serum; vancomycin pediatric; free mass ... See more keywords
Biomechanical and microbiological effects of local vancomycin in anterior cruciate ligament (ACL) reconstruction: a porcine tendon model
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DOI: 10.1007/s00402-018-3006-x
Abstract: IntroductionAlthough there is increasing evidence for the successful use of local vancomycin applied by soaked compresses during ACL reconstruction, there are still little data on its microbiological and biomechanical effects. Furthermore, exact dosage of vancomycin… read more here.
Keywords: vancomycin; acl reconstruction; local vancomycin; contamination ... See more keywords
Evaluation of the clinical relevance of vancomycin for the treatment of Lyme disease
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DOI: 10.1007/s00508-019-1505-6
Abstract: SummaryVancomycin is active in vitro and in vivo in mouse systems against Lyme disease borrelia; however, there are no published data on the efficacy of vancomycin in patients with Lyme disease and no convincing theoretical… read more here.
Keywords: vancomycin; clinical relevance; evaluation clinical; treatment ... See more keywords
Vancomycin-Induced Changes in Host Immunity and Behavior: Comparative Genomic and Metagenomic Analysis in C57BL/6 and BALB/c Mice
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DOI: 10.1007/s10620-020-06729-x
Abstract: Background The consequence of treatment with antibiotics on the gut microbiota can be destructive. The antibiotics, however, can be utilized to understand the role of gut microbiota on the host physiology. Aim Earlier, we reported… read more here.
Keywords: vancomycin; immunity; gut; gut microbiota ... See more keywords
Comparison of the effect of teicoplanin and vancomycin on experimental methicillin-resistant staphylococcus aureus keratitis
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DOI: 10.1007/s10792-021-01696-2
Abstract: To evaluate the early efficacy and safety of intrastromal injection of teicoplanin as the alternative treatment for the methicillin-resistant Staphylococcus aureus (MRSA) keratitis by comparing it with vancomycin. Twenty-four eyes of 24 New Zealand white… read more here.
Keywords: vancomycin; treatment; resistant staphylococcus; methicillin resistant ... See more keywords
Successful response of primary sclerosing cholangitis and associated ulcerative colitis to oral vancomycin may depend on brand and personalized dose: report in an adolescent
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DOI: 10.1007/s12328-020-01296-0
Abstract: Primary sclerosing cholangitis (PSC) is a rare, progressive liver disease characterized by cholestasis and bile duct fibrosis that has no accepted therapy known to delay or arrest its progression. We report a 23-year-old female patient… read more here.
Keywords: vancomycin; primary sclerosing; ulcerative colitis; oral vancomycin ... See more keywords
Open-Label Randomized Trial of Early Clinical Outcomes of Ceftaroline Fosamil Versus Vancomycin for the Treatment of Acute Bacterial Skin and Skin Structure Infections at Risk of Methicillin-Resistant Staphylococcus aureus
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DOI: 10.1007/s40121-019-0242-5
Abstract: IntroductionAcute bacterial skin and skin structure infections (ABSSSIs) remain among the most common infectious processes seen in the clinical setting. For patients with complicated ABSSSIs deemed to require intravenous antibiotics, vancomycin remains the mainstay therapy.… read more here.
Keywords: vancomycin; trial; skin skin; skin ... See more keywords