Optimal vancomycin dosing regimens for critically ill patients with acute kidney injury during continuous renal replacement therapy: A Monte Carlo simulation study.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of critical care"
DOI: 10.1016/j.jcrc.2019.07.008
Abstract: PURPOSE This study aims to determine the optimal vancomycin dosing in critically ill patients with acute kidney injury receiving continuous renal replacement therapy (CRRT) using Monte Carlo simulation. METHODS A one compartment pharmacokinetic model was… read more here.
Keywords: ill patients; therapy; critically ill; vancomycin ... See more keywords
A machine learning model that emulates experts' decision making in vancomycin initial dose planning.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of pharmacological sciences"
DOI: 10.1016/j.jphs.2022.02.005
Abstract: Vancomycin is a glycopeptide antibiotic that is a primary treatment for methicillin-resistant Staphylococcus aureus infections. To enhance its clinical effectiveness and prevent nephrotoxicity, therapeutic drug monitoring (TDM) of trough concentrations is recommended. Initial vancomycin dosing… read more here.
Keywords: vancomycin initial; decision making; machine learning; model ... See more keywords
Individualized Empiric Vancomycin Dosing in Neonates Using a Model-Based Approach.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Pediatric Infectious Diseases Society"
DOI: 10.1093/jpids/pix109
Abstract: BACKGROUND Vancomycin dosing in neonates is challenging because of the large variation in pharmacokinetics. Existing empiric dosing recommendations use table-based formats, within which a neonate is categorized on the basis of underlying characteristics. The ability… read more here.
Keywords: model based; vancomycin dosing; neo vanco; dosing neonates ... See more keywords
In Outpatients Receiving Parenteral Vancomycin, Dosing Adjustments Produced by Area Under the Curve-Based and Trough-Based Monitoring Differ Only at the Extremes of the Therapeutic Trough Range
Sign Up to like & getrecommendations! Published in 2023 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofac696
Abstract: Abstract Area under the curve (AUC)-based vancomycin dosing reduces nephrotoxicity but is burdensome. Reviewing 115 adults receiving ≥2 weeks of outpatient vancomycin, we found AUC-based and trough-based dose adjustments discordant only for troughs 16 mg/L. Selective… read more here.
Keywords: vancomycin; vancomycin dosing; based trough; trough based ... See more keywords
2332. Higher Pediatric Vancomycin Dosing Trends Toward Improved Therapeutic Troughs
Sign Up to like & getrecommendations! Published in 2018 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofy210.1985
Abstract: Abstract Background Vancomycin is challenging to dose due to a narrow therapeutic index. Inadequate dosing undertreats dangerous infections, while high doses can cause Acute Kidney Injury (AKI). Standard pediatric vancomycin dosing (40–60 mg/kg/day) often produces… read more here.
Keywords: vancomycin; initial trough; therapeutic troughs; rate ... See more keywords
Maturational changes in vancomycin protein binding affect vancomycin dosing in neonates
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Clinical Pharmacology"
DOI: 10.1111/bcp.13899
Abstract: Optimal dosing of vancomycin in neonates remains a matter of debate despite the frequent use of vancomycin in neonatal intensive care units (NICUs). The optimal use of vancomycin requires knowledge of its pharmacokinetics (PK) and… read more here.
Keywords: vancomycin; auc24 mic; maturational changes; dosing neonates ... See more keywords
Comparison of open‐access vancomycin dosing websites
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Pharmacy and Therapeutics"
DOI: 10.1111/jcpt.12466
Abstract: There are many methods for dosing vancomycin. The purpose of this commentary was to compare open‐access vancomycin dosing websites with Vancomycin‐Calculator.com and describe how body weight can affect their pharmacokinetic (PK) calculations. read more here.
Keywords: vancomycin; open access; dosing websites; vancomycin dosing ... See more keywords
Assessment of an online calculator's vancomycin dosing and exposure appropriateness in persons who inject drugs with methicillin-resistant Staphylococcus aureus bloodstream infections.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of clinical pharmacy and therapeutics"
DOI: 10.1111/jcpt.13603
Abstract: WHAT IS KNOWN AND OBJECTIVE While the gold standard for calculating AUC involves two steady-state concentrations, online calculators can empirically estimate AUC and other pharmacokinetic (PK) parameters. In patients with potentially altered PK, such as… read more here.
Keywords: online calculator; vancomycin dosing; persons inject; inject drugs ... See more keywords
Safety and Feasibility Assessment of a Pharmacy-Driven AUC/MIC Vancomycin Dosing Protocol in a Multicenter Hospital System
Sign Up to like & getrecommendations! Published in 2023 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.03313-22
Abstract: In this article, we report that there were no differences in rates of acute kidney injury between trough-based vancomycin dosing and AUC/MIC-based vancomycin dosing across 12 hospitals. AUC/MIC dosing resulted in more vancomycin lab draws… read more here.
Keywords: lab; vancomycin; vancomycin dosing; auc mic ... See more keywords
O13 Improved early vancomycin exposure in neonates using a population pharmacokinetic model-based vancomycin dosing regimen
Sign Up to like & getrecommendations! Published in 2019 at "Archives of Disease in Childhood"
DOI: 10.1136/archdischild-2019-esdppp.13
Abstract: Background We previously documented that 2 published vancomycin dosing regimens resulted in subtherapeutic exposure in 66.3 and 76.2% of neonates.1 A new dosing regimen derived from a population pharmacokinetic (PK) analysis and using a loading… read more here.
Keywords: vancomycin exposure; exposure; vancomycin dosing; dosing regimen ... See more keywords
Evaluation of Vancomycin Dosing in Patients With Cirrhosis: Beginning De-Liver-ations about a New Nomogram
Sign Up to like & getrecommendations! Published in 2019 at "Hospital Pharmacy"
DOI: 10.1177/0018578718772266
Abstract: Background: Reduced hepatic production of creatinine precursors in patients with decompensated cirrhosis leads to falsely low serum creatinine values. Therefore, when performing empiric dosing of vancomycin, an overestimation of creatinine clearance may result in significantly… read more here.
Keywords: vancomycin; patients cirrhosis; evaluation; vancomycin dosing ... See more keywords