New insights into the vancomycin‐induced nephrotoxicity using in vitro metabolomics combined with physiologically based pharmacokinetic modeling
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.3951
Abstract: Vancomycin is a first‐line treatment for invasive infections caused by multidrug‐resistant gram‐positive bacteria. However, vancomycin‐induced nephrotoxicity is an increasing burden, particularly in patients with complex life‐threatening conditions. Vancomycin‐induced nephrotoxicity associated with clinically relevant exposure on… read more here.
Keywords: vancomycin; based pharmacokinetic; induced nephrotoxicity; physiologically based ... See more keywords
Vancomycin-induced nephrotoxicity in non-intensive care unit pediatric patients
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DOI: 10.1038/s41598-021-00214-9
Abstract: Previous data suggested several risk factors for vancomycin-induced nephrotoxicity (VIN), including higher daily dose, long-term use, underlying renal disease, intensive care unit (ICU) admission, and concomitant use of nephrotoxic medications. We conducted this study to… read more here.
Keywords: vancomycin induced; serum trough; pediatric patients; trough level ... See more keywords
Using Japanese big data to investigate novel factors and their high‐risk combinations that affect vancomycin‐induced nephrotoxicity
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Clinical Pharmacology"
DOI: 10.1111/bcp.15252
Abstract: Several factors related to vancomycin‐induced nephrotoxicity (VIN) have not yet been clarified. In the present study, we used Japanese big data to investigate novel factors and their high‐risk combinations that influence VIN. read more here.
Keywords: vancomycin induced; japanese big; big data; data investigate ... See more keywords
Vancomycin-induced linear Immunoglobulin A bullous dermatosis
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DOI: 10.1136/bcr-2019-233281
Abstract: A 72-year-old woman with a history of left hip prosthetic joint infection (PJI) on parenteral antibiotics presented with rash. Prior to this presentation, she was diagnosed with PJI of her left hip, for which she… read more here.
Keywords: vancomycin induced; bullous dermatosis; linear immunoglobulin; immunoglobulin bullous ... See more keywords
Biopsy-proven vancomycin-induced acute kidney injury: a case report and literature review
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DOI: 10.1186/s12882-018-0845-1
Abstract: BackgroundVancomycin is the first-line antibiotic for methicillin-resistant Staphylococcus aureus and coagulase-negative strains. The risk of vancomycin-induced acute kidney injury increases with plasma vancomycin levels. Vancomycin-induced acute kidney injury is histologically characterized by acute interstitial nephritis… read more here.
Keywords: kidney injury; acute kidney; vancomycin induced; injury ... See more keywords
Vancomycin induced cardiac arrest: a case report
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Medical Case Reports"
DOI: 10.1186/s13256-020-02639-8
Abstract: Background Rapid intravenous administration of vancomycin may manifest with histaminergic responses with clinical features ranging from mild rashes, pruritus and even shock. This case reports of a child, who was accidentally given intravenous vancomycin within… read more here.
Keywords: vancomycin; arrest case; case; cardiac arrest ... See more keywords
Associations of HLA-A and HLA-B with vancomycin-induced drug reaction with eosinophilia and systemic symptoms in the Han-Chinese population
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.954596
Abstract: Vancomycin is a commonly used antibiotic; however, it can cause life-threatening severe cutaneous adverse reactions, such as drug reaction with eosinophilia and systemic symptoms (DRESS). A previous study has reported a strong association between HLA-A*32:01… read more here.
Keywords: vancomycin induced; induced dress; vancomycin; hla hla ... See more keywords
LTT and HLA testing as diagnostic tools in Spanish vancomycin-induced DRESS cases: A case-control study
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.959321
Abstract: Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe T-cell-mediated off-target adverse reaction. DRESS cases caused by vancomycin have often been reported. The HLA-A*32:01 allele has been associated with genetic susceptibility to vancomycin-induced… read more here.
Keywords: vancomycin induced; induced dress; vancomycin; hla ... See more keywords
Nephroprotective potential of Polyalthia longifolia roots against vancomycin-induced renal toxicity in experimental animals
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DOI: 10.3389/fphar.2023.1107435
Abstract: This study was done to investigate the possible nephroprotective effect of an ethanolic root extract of Polyalthia Longifolia (PL) on vancomycin-induced nephrotoxicity using curative and protective models. Vancomycin (150 mg/kg, intravenous) was given to healthy… read more here.
Keywords: vancomycin induced; polyalthia longifolia; group; selenium ... See more keywords
Resveratrol Ameliorates Vancomycin-Induced Testicular Dysfunction in Male Rats
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DOI: 10.3390/medicina59030486
Abstract: Background and Objectives: Numerous studies have indicated that antibiotics may adversely affect testicular and sperm function. As an alternative to penicillin, vancomycin is a glycopeptide antibiotic developed to treat resistant strains of Staphylococcus aureus. A… read more here.
Keywords: vancomycin induced; testicular toxicity; vancomycin; resveratrol ... See more keywords