Zn(II) mediates vancomycin polymerization and potentiates its antibiotic activity against resistant bacteria
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DOI: 10.1038/s41598-017-04868-2
Abstract: Vancomycin is known to bind to Zn(II) and can induce a zinc starvation response in bacteria. Here we identify a novel polymerization of vancomycin dimers by structural analysis of vancomycin-Zn(II) crystals and fibre X-ray diffraction.… read more here.
Keywords: polymerization; mediates vancomycin; antibiotic activity; vancomycin polymerization ... See more keywords