Molecular mechanisms of vancomycin resistance
Sign Up to like & getrecommendations! Published in 2020 at "Protein Science"
DOI: 10.1002/pro.3819
Abstract: Vancomycin and related glycopeptides are drugs of last resort for the treatment of severe infections caused by Gram‐positive bacteria such as Enterococcus species, Staphylococcus aureus, and Clostridium difficile. Vancomycin was long considered immune to resistance… read more here.
Keywords: vancomycin; mechanisms vancomycin; resistance; vancomycin resistance ... See more keywords
Structural insights into DNA binding domain of vancomycin‐resistance‐associated response regulator in complex with its promoter DNA from Staphylococcus aureus
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DOI: 10.1002/pro.4286
Abstract: In Staphylococcus aureus, vancomycin‐resistance‐associated response regulator (VraR) is a part of the VraSR two‐component system, which is responsible for activating a cell wall‐stress stimulon in response to an antibiotic that inhibits cell wall formation. Two… read more here.
Keywords: dna; vancomycin resistance; dna binding; staphylococcus aureus ... See more keywords
Quantification of the d-Ala-d-Lac-Terminated Peptidoglycan Structure in Vancomycin-Resistant Enterococcus faecalis Using a Combined Solid-State Nuclear Magnetic Resonance and Mass Spectrometry Analysis.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemistry"
DOI: 10.1021/acs.biochem.6b00774
Abstract: Induction of vancomycin resistance in vancomycin-resistant enterococci (VRE) involves replacement of the d-Ala-d-Ala terminus of peptidoglycan (PG) stems with d-Ala-d-Lac, dramatically reducing the binding affinity of vancomycin for lipid II. Effects from vancomycin resistance induction… read more here.
Keywords: vancomycin; ala lac; solid state; vancomycin resistance ... See more keywords
Antagonizing vancomycin resistance in Enterococcus by surface localized antimicrobial display (SLAY)-derived peptides.
Sign Up to like & getrecommendations! Published in 2019 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.9b00164
Abstract: Decreasing therapeutic pipeline for vancomycin-resistant Enterococcus (VRE) calls for novel strategies to enhance our antibacterial arsenal. Herein, we investigated the potential applications of surface localized antimicrobial display (SLAY)-derived cationic peptides in the fight against VanA… read more here.
Keywords: vancomycin; slay derived; slay; enterococcus ... See more keywords
Increasing trend in enterococcal bacteraemia and vancomycin resistance in a tertiary care hospital in Croatia, 2017–2021
Sign Up to like & getrecommendations! Published in 2022 at "Infectious Diseases"
DOI: 10.1080/23744235.2022.2131901
Abstract: Abstract Background The epidemiology of enterococcal bacteraemia has changed worldwide and vancomycin-resistant enterococci increasingly cause healthcare-associated infections) with limited treatment options. Studies show heterogeneity among countries, regions and individual hospitals. Methods We retrospectively analysed enterococcal… read more here.
Keywords: vancomycin resistance; bacteraemia; hospital; enterococcal bacteraemia ... See more keywords
502. Enhanced Sporulation and Vancomycin Resistance Associated With Clostridium difficile From Recurrent Infections
Sign Up to like & getrecommendations! Published in 2018 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofy210.511
Abstract: Abstract Background Recurrent Clostridium difficile infection (R-CDI) remains a significant healthcare problem. Our aim was to analyze sporulation and antimicrobial resistance of C. difficile in biofilms as a potential reservoir for recurrence. Methods C. difficile… read more here.
Keywords: cdi; difficile; biofilm; resistance ... See more keywords
Mitoxantrone targets both host and bacteria to overcome vancomycin resistance in Enterococcus faecalis
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DOI: 10.1126/sciadv.add9280
Abstract: Among Enterococci, intrinsic and acquired resistance to antibiotics such as β-lactams and vancomycin critically limit treatment options for infection with these opportunistic pathogens. Antimicrobials that enhance the host immune response are emerging as alternative approaches,… read more here.
Keywords: vancomycin resistance; mitoxantrone; enterococcus faecalis; activity ... See more keywords
Knockout of ykcB, a Putative Glycosyltransferase, Leads to Reduced Susceptibility to Vancomycin in Bacillus subtilis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bacteriology"
DOI: 10.1128/jb.00387-22
Abstract: Although vancomycin is effective against Gram-positive bacteria, vancomycin-resistant bacteria are a major public health concern. While the vancomycin-resistance mechanisms of clinically important bacteria such as Staphylococcus aureus, Enterococcus faecium, and Streptococcus pneumoniae are well studied,… read more here.
Keywords: vancomycin resistance; vancomycin; positive bacteria; susceptibility ... See more keywords
Vancomycin Resistance in Enterococcus faecium from the Dallas, Texas, Area Is Conferred Predominantly on pRUM-Like Plasmids
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DOI: 10.1128/msphere.00024-23
Abstract: Vancomycin is an antibiotic used to treat infections caused by multidrug-resistant Gram-positive bacteria. Vancomycin resistance is common in clinical isolates of the Gram-positive pathogen Enterococcus faecium. ABSTRACT Vancomycin-resistant E. faecium (VREfm) is a significant public… read more here.
Keywords: vancomycin resistance; enterococcus faecium; area; prum like ... See more keywords
Evaluation of commercial veterinary probiotics containing enterococci for transferrable vancomycin resistance genes
Sign Up to like & getrecommendations! Published in 2020 at "BMC Research Notes"
DOI: 10.1186/s13104-020-05114-1
Abstract: Objective Vancomycin resistant enterococci (VRE) are of significant public health concern. The identification of VRE in livestock and food has increased. The objective of this study was to determine if the transferrable vancomycin resistance genes… read more here.
Keywords: vancomycin; transferrable vancomycin; vancomycin resistance; resistance genes ... See more keywords
The importance of adjusting for enterococcus species when assessing the burden of vancomycin resistance: a cohort study including over 1000 cases of enterococcal bloodstream infections
Sign Up to like & getrecommendations! Published in 2018 at "Antimicrobial Resistance and Infection Control"
DOI: 10.1186/s13756-018-0419-9
Abstract: BackgroundInfections caused by vancomycin-resistant enterococci (VRE) are on the rise worldwide. Few studies have tried to estimate the mortality burden as well as the financial burden of those infections and found that VRE are associated… read more here.
Keywords: burden; enterococcus species; resistance; vancomycin resistance ... See more keywords