Optimizing vancomycin dosing in pediatrics: a machine learning approach to predict trough concentrations in children under four years of age
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Clinical Pharmacy"
DOI: 10.1007/s11096-024-01745-7
Abstract: Vancomycin trough concentration is closely associated with clinical efficacy and toxicity. Predicting vancomycin trough concentrations in pediatric patients is challenging due to significant inter-individual variability and rapid physiological changes during maturation. This study aimed to… read more here.
Keywords: machine learning; vancomycin trough; years age; trough concentrations ... See more keywords
Association of Vancomycin Trough Concentration With Response to Treatment for Acute Pulmonary Exacerbation of Cystic Fibrosis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the Pediatric Infectious Diseases Society"
DOI: 10.1093/jpids/pix043
Abstract: Background Our goal was to determine the relationship between serum vancomycin trough concentrations (VTCs) and changes in pulmonary function among individuals with an acute pulmonary exacerbation (APE) of cystic fibrosis (CF). Methods We included subjects… read more here.
Keywords: cystic fibrosis; vancomycin trough; pulmonary function; acute pulmonary ... See more keywords
Big Data Bayesian Truths: No Vancomycin Trough Concentration Target Is Sufficiently Precise for Safety or Efficacy
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DOI: 10.1093/ofid/ofaf041
Abstract: Abstract Introduction Therapeutic drug monitoring is standard of care for vancomycin because of the known efficacy and safety exposure window (ie, area under the concentration-time curve [AUC] of 400–600 mg × 24 hours/L). Despite guideline recommendations, AUCs… read more here.
Keywords: cmin auc; vancomycin trough; auc; target ... See more keywords
Relationship between Vancomycin Trough Serum Concentrations and Clinical Outcomes in Children: a Systematic Review and Meta-Analysis
Sign Up to like & getrecommendations! Published in 2022 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00138-22
Abstract: To systematically evaluate the relationships between vancomycin trough serum concentrations and clinical outcomes in children using meta-analysis. Several databases, including PubMed, Elsevier, Web of Science, EMBASE, Medline, clinicaltrials.gov, the Cochrane Library, and three Chinese databases… read more here.
Keywords: meta analysis; trough serum; analysis; serum concentrations ... See more keywords
Are Vancomycin Trough Concentrations of 15 to 20 mg/L Associated With Increased Attainment of an AUC/MIC ≥ 400 in Patients With Presumed MRSA Infection?
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pharmacy Practice"
DOI: 10.1177/0897190016642692
Abstract: Purpose: To determine whether there is an association between higher vancomycin trough concentrations and attainment of a calculated area under the concentration–time curve (AUC)/minimum inhibitory concentration (MIC) ≥400. Methods: A retrospective analysis was conducted among… read more here.
Keywords: vancomycin trough; auc mic; trough concentrations; mic 400 ... See more keywords
Effect of low vs. high vancomycin trough level on the clinical outcomes of adult patients with sepsis or gram-positive bacterial infections: a systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2024 at "BMC Infectious Diseases"
DOI: 10.1186/s12879-024-09927-4
Abstract: The Infectious Disease Society of America guidelines recommend vancomycin trough levels of 15–20 mg/L for severe methicillin-resistant Staphylococcus aureus. However, recent consensus guidelines of four infectious disease organizations no longer recommend vancomycin dosing using minimum… read more here.
Keywords: outcomes adult; analysis; clinical outcomes; trough levels ... See more keywords
Vancomycin trough level and loading dose
Sign Up to like & getrecommendations! Published in 2018 at "Infection and Drug Resistance"
DOI: 10.2147/idr.s184897
Abstract: php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from… read more here.
Keywords: drug resistance; level loading; vancomycin trough; infection drug ... See more keywords