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   Articles with "vangl2" as a keyword



The formation of paranodal spirals at the ends of CNS myelin sheaths requires the planar polarity protein Vangl2

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recommendations! Published in 2020 at "Glia"

DOI: 10.1002/glia.23809

Abstract: During axonal ensheathment, noncompact myelin channels formed at lateral edges of the myelinating process become arranged into tight paranodal spirals that resemble loops when cut in cross section. These adhere to the axon, concentrating voltage‐dependent… read more here.

Keywords: paranodal spirals; vangl2; adhesion; polarity ... See more keywords

Vangl2 limits chaperone-mediated autophagy to balance osteogenic differentiation in mesenchymal stem cells.

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recommendations! Published in 2021 at "Developmental cell"

DOI: 10.1016/j.devcel.2021.06.011

Abstract: Lysosomes are the recycling center and nutrient signaling hub of the cell. Here, we show that lysosomes also control mesenchymal stem cell (MSC) differentiation by proteomic reprogramming. The chaperone-mediated autophagy (CMA) lysosome subgroup promotes osteogenesis,… read more here.

Keywords: vangl2; mediated autophagy; chaperone mediated; differentiation ... See more keywords

VANGL2 interacts with integrin &agr;v to regulate matrix metalloproteinase activity and cell adhesion to the extracellular matrix

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recommendations! Published in 2017 at "Experimental Cell Research"

DOI: 10.1016/j.yexcr.2017.10.026

Abstract: ABSTRACT Planar cell polarity (PCP) proteins are implicated in a variety of morphogenetic processes including embryonic cell migration and potentially cancer progression. During zebrafish gastrulation, the transmembrane protein Vang‐like 2 (VANGL2) is required for PCP… read more here.

Keywords: vangl2; integrin agr; matrix; adhesion ... See more keywords

Stearoylation cycle regulates the cell surface distribution of the PCP protein Vangl2

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recommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2400569121

Abstract: Significance Planar cell polarity (PCP) signaling is crucial for cell–cell communication in health and disease. Thus, understanding molecular regulation mechanism of PCP is of both fundamental and translational importance. Dysregulation of the core PCP component… read more here.

Keywords: pcp; vangl2; cell; stearoylation cycle ... See more keywords

Dihydroartemisinin Attenuates Hypoxic Pulmonary Hypertension via the Downregulation of miR-335 Targeting Vangl2.

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recommendations! Published in 2022 at "DNA and cell biology"

DOI: 10.1089/dna.2021.1113

Abstract: Dihydroartemisinin (DHA) is a traditional antimalarial drug. DHA plays a crucial role in preventing pulmonary hypertension (PH); however, its regulatory function on microRNAs (miRNAs) in PH remains unclear. This study aimed to investigate whether DHA… read more here.

Keywords: proliferation migration; hypoxia induced; mir 335; dha ... See more keywords

Abstract 339: Identification of a novel isoform of WNT/planar cell polarity VANGL2 in breast cancer

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recommendations! Published in 2017 at "Cancer Research"

DOI: 10.1158/1538-7445.am2017-339

Abstract: The WNT/PCP pathway is an evolutionarily conserved developmental process which is essential in embryogenesis and development of polarized structures in metazoans. Its importance in human diseases is best demonstrated in neural tube closure defects and… read more here.

Keywords: vangl2; wnt; breast cancer; cancer ... See more keywords

The bidirectional relationship between cilia and PCP signaling pathway core protein Vangl2

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recommendations! Published in 2025 at "Science Progress"

DOI: 10.1177/00368504241311964

Abstract: Vangl2, a core component of the PCP signaling pathway, serves as a scaffold protein on the cell membrane, playing a crucial role in organizing protein complexes. Cilia, dynamic structures on the cell surface, carry out… read more here.

Keywords: cilia; core; pcp signaling; vangl2 ... See more keywords

VANGL2 alleviates inflammatory bowel disease by recruiting the ubiquitin ligase MARCH8 to limit NLRP3 inflammasome activation through OPTN-mediated selective autophagy

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recommendations! Published in 2025 at "PLOS Biology"

DOI: 10.1371/journal.pbio.3002961

Abstract: Inflammatory bowel disease (IBD) is a chronic and potentially life-threatening inflammatory disease of gastroenteric tissue characterized by episodes of intestinal inflammation, but the underlying mechanisms remain elusive. Here, we explore the role and precise mechanism… read more here.

Keywords: disease; inflammasome activation; vangl2; nlrp3 inflammasome ... See more keywords

The Planar Polarity Component VANGL2 Is a Key Regulator of Mechanosignaling

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recommendations! Published in 2020 at "Frontiers in Cell and Developmental Biology"

DOI: 10.3389/fcell.2020.577201

Abstract: VANGL2 is a component of the planar cell polarity (PCP) pathway, which regulates tissue polarity and patterning. The Vangl2Lp mutation causes lung branching defects due to dysfunctional actomyosin-driven morphogenesis. Since the actomyosin network regulates cell… read more here.

Keywords: planar polarity; vangl2; polarity component; component vangl2 ... See more keywords