The formation of paranodal spirals at the ends of CNS myelin sheaths requires the planar polarity protein Vangl2
Sign Up to like & getrecommendations! Published in 2020 at "Glia"
DOI: 10.1002/glia.23809
Abstract: During axonal ensheathment, noncompact myelin channels formed at lateral edges of the myelinating process become arranged into tight paranodal spirals that resemble loops when cut in cross section. These adhere to the axon, concentrating voltage‐dependent… read more here.
Keywords: paranodal spirals; vangl2; adhesion; polarity ... See more keywords
Vangl2 limits chaperone-mediated autophagy to balance osteogenic differentiation in mesenchymal stem cells.
Sign Up to like & getrecommendations! Published in 2021 at "Developmental cell"
DOI: 10.1016/j.devcel.2021.06.011
Abstract: Lysosomes are the recycling center and nutrient signaling hub of the cell. Here, we show that lysosomes also control mesenchymal stem cell (MSC) differentiation by proteomic reprogramming. The chaperone-mediated autophagy (CMA) lysosome subgroup promotes osteogenesis,… read more here.
Keywords: vangl2; mediated autophagy; chaperone mediated; differentiation ... See more keywords
VANGL2 interacts with integrin &agr;v to regulate matrix metalloproteinase activity and cell adhesion to the extracellular matrix
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2017.10.026
Abstract: ABSTRACT Planar cell polarity (PCP) proteins are implicated in a variety of morphogenetic processes including embryonic cell migration and potentially cancer progression. During zebrafish gastrulation, the transmembrane protein Vang‐like 2 (VANGL2) is required for PCP… read more here.
Keywords: vangl2; integrin agr; matrix; adhesion ... See more keywords
Dihydroartemisinin Attenuates Hypoxic Pulmonary Hypertension via the Downregulation of miR-335 Targeting Vangl2.
Sign Up to like & getrecommendations! Published in 2022 at "DNA and cell biology"
DOI: 10.1089/dna.2021.1113
Abstract: Dihydroartemisinin (DHA) is a traditional antimalarial drug. DHA plays a crucial role in preventing pulmonary hypertension (PH); however, its regulatory function on microRNAs (miRNAs) in PH remains unclear. This study aimed to investigate whether DHA… read more here.
Keywords: proliferation migration; hypoxia induced; mir 335; dha ... See more keywords
Abstract 339: Identification of a novel isoform of WNT/planar cell polarity VANGL2 in breast cancer
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-339
Abstract: The WNT/PCP pathway is an evolutionarily conserved developmental process which is essential in embryogenesis and development of polarized structures in metazoans. Its importance in human diseases is best demonstrated in neural tube closure defects and… read more here.
Keywords: vangl2; wnt; breast cancer; cancer ... See more keywords
The Planar Polarity Component VANGL2 Is a Key Regulator of Mechanosignaling
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2020.577201
Abstract: VANGL2 is a component of the planar cell polarity (PCP) pathway, which regulates tissue polarity and patterning. The Vangl2Lp mutation causes lung branching defects due to dysfunctional actomyosin-driven morphogenesis. Since the actomyosin network regulates cell… read more here.
Keywords: planar polarity; vangl2; polarity component; component vangl2 ... See more keywords