Facile Synthesis of Novel Vanillin Derivatives Incorporating a Bis(2-hydroxyethyl)dithhioacetal Moiety as Antiviral Agents.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.7b01035
Abstract: A series of vanillin derivatives incorporating a bis(2-hydroxyethyl)dithioacetal moiety was designed and synthesized via a facile method. A plausible reaction pathway was proposed and verified by computational studies. Bioassay results demonstrated that target compounds possessed… read more here.
Keywords: bis hydroxyethyl; derivatives incorporating; vanillin derivatives; incorporating bis ... See more keywords
Synthesis of novel vanillin derivatives: novel multi-targeted scaffold ligands against Alzheimer's disease.
Sign Up to like & getrecommendations! Published in 2019 at "MedChemComm"
DOI: 10.1039/c9md00048h
Abstract: Alzheimer's disease (AD) is the most common cause of dementia worldwide, normally affecting people aged over 65. Due to the multifactorial nature of this disease, a "multi-target-directed ligands" (MTDLs) approach for the treatment of this… read more here.
Keywords: vanillin derivatives; alzheimer disease; disease; multi targeted ... See more keywords
Synthesis, Antileishmanial Activity, and in silico Study of 2-Hydroxy-3-(1,2,3-triazolyl)propyl Vanillin Derivatives
Sign Up to like & getrecommendations! Published in 2025 at "Journal of the Brazilian Chemical Society"
DOI: 10.21577/0103-5053.20240200
Abstract: This study details the preparation, antileishmanial assay, and in silico analysis of twenty 2-hydroxy-3-(1,2,3-triazolyl)propyl vanillin derivatives. These compounds were synthesized in three steps and evaluated against Leishmania infantum, Leishmania amazonensis, and Leishmania braziliensis promastigotes. Compounds… read more here.
Keywords: triazolyl propyl; propyl vanillin; vanillin derivatives; hydroxy triazolyl ... See more keywords
2-Hydroxy-4-methoxybenzaldehyde, a more effective antifungal aroma than vanillin and its derivatives against Fusarium graminearum, destroys cell membranes, inhibits DON biosynthesis, and performs a promising antifungal effect on wheat grains
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2024.1359947
Abstract: Fusarium graminearum (F. graminearum) is a severe pathogen threatening the safety of agriculture and food. This study aimed to explore the antifungal efficacies of several plant-derived natural compounds (vanillin and its derivatives) against the growth… read more here.
Keywords: antifungal effect; vanillin derivatives; cell membranes; fusarium graminearum ... See more keywords