α-Synuclein binds to the ER–mitochondria tethering protein VAPB to disrupt Ca2+ homeostasis and mitochondrial ATP production
Sign Up to like & getrecommendations! Published in 2017 at "Acta Neuropathologica"
DOI: 10.1007/s00401-017-1704-z
Abstract: Abstractα-Synuclein is strongly linked to Parkinson’s disease but the molecular targets for its toxicity are not fully clear. However, many neuronal functions damaged in Parkinson’s disease are regulated by signalling between the endoplasmic reticulum (ER)… read more here.
Keywords: protein; protein vapb; vapb; parkinson disease ... See more keywords
Caspar, an adapter for VAPB and TER94, modulates the progression of ALS8 by regulating IMD/NFκB-mediated glial inflammation in a Drosophila model of human disease
Sign Up to like & getrecommendations! Published in 2022 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddac076
Abstract: Abstract Amyotrophic lateral sclerosis (ALS) is a fatal, late-onset, progressive motor neurodegenerative disorder. A key pathological feature of the disease is the presence of heavily ubiquitinated protein inclusions. Both the unfolded protein response and the… read more here.
Keywords: vapb; inflammation; ter94; disease ... See more keywords
Stay or Go: Sulfolobales Biofilm Dispersal Is Dependent on a Bifunctional VapB Antitoxin
Sign Up to like & getrecommendations! Published in 2023 at "mBio"
DOI: 10.1128/mbio.00053-23
Abstract: Biofilms allow microbes to resist a multitude of stresses and stay proximate to vital nutrients. The mechanisms of entering and leaving a biofilm are highly regulated to ensure microbial survival, but are not yet well… read more here.
Keywords: vapb; biofilm dispersal; toxin; antitoxin ... See more keywords
A SNX1–SNX2–VAPB partnership regulates endosomal membrane rewiring in response to nutritional stress
Sign Up to like & getrecommendations! Published in 2022 at "Life Science Alliance"
DOI: 10.26508/lsa.202201652
Abstract: A specific SNX1-dependent endosome tubulation towards autophagosome biogenesis-associated regions of the ER is generated by nutrient deprivation and regulated by the SNX2/VAPB tethering complex. Nutrient deprivation (“starvation”) is a major catabolic stress faced by mammalian… read more here.
Keywords: snx1; vapb; stress; nutritional stress ... See more keywords
Disruption of the VAPB-PTPIP51 ER-mitochondria tethering proteins in post-mortem human amyotrophic lateral sclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.950767
Abstract: Signaling between the endoplasmic reticulum (ER) and mitochondria regulates many neuronal functions that are perturbed in amyotrophic lateral sclerosis (ALS) and perturbation to ER-mitochondria signaling is seen in cell and transgenic models of ALS. However,… read more here.
Keywords: amyotrophic lateral; vapb; post mortem; vapb ptpip51 ... See more keywords