Novel adenovirus encoded virus-like particles displaying the placental malaria associated VAR2CSA antigen.
Sign Up to like & getrecommendations! Published in 2017 at "Vaccine"
DOI: 10.1016/j.vaccine.2017.01.016
Abstract: The malaria parasite Plasmodium falciparum presents antigens on the infected erythrocyte surface that bind human receptors expressed on the vascular endothelium. The VAR2CSA mediated binding to a distinct chondroitin sulphate A (CSA) is a crucial… read more here.
Keywords: var2csa; placental malaria; adenovirus encoded; encoded virus ... See more keywords
mSphere of Influence: Structural Insights into the Molecular Mechanism Underlying Placental Malaria
Sign Up to like & getrecommendations! Published in 2021 at "mSphere"
DOI: 10.1128/msphere.00391-21
Abstract: Maria del Pilar Quintana works on immunology and pathogenesis of severe malaria. In this mSphere of Influence article, she reflects on how the papers “Structural basis for placental malaria mediated by Plasmodium falciparum VAR2CSA” (R).… read more here.
Keywords: msphere influence; immunology; malaria; var2csa ... See more keywords
A conformational epitope in placental malaria vaccine antigen VAR2CSA: What does it teach us?
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DOI: 10.1371/journal.ppat.1011370
Abstract: VAR2CSA is the Plasmodium falciparum variant surface antigen that mediates binding of infected erythrocytes to chondroitin sulfate A (CSA) and their sequestration in intervillous spaces of the placenta, leading to placental malaria (PM). Relatively high… read more here.
Keywords: epitope; conformational epitope; var2csa; placental malaria ... See more keywords
High Antibodies to VAR2CSA in Response to Malaria Infection Are Associated With Improved Birthweight in a Longitudinal Study of Pregnant Women
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.644563
Abstract: Introduction Pregnant women have an increased risk of P. falciparum infection, which is associated with low birth weight and preterm delivery. VAR2CSA, a variant surface antigen expressed on the parasitized erythrocyte surface, enables sequestration in… read more here.
Keywords: pregnancy; response; var2csa; pregnant women ... See more keywords
Polymorphic Molecular Signatures in Variable Regions of the Plasmodium falciparum var2csa DBL3x Domain Are Associated with Virulence in Placental Malaria
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DOI: 10.3390/pathogens11050520
Abstract: The Plasmodium falciparum protein VAR2CSA allows infected erythrocytes to accumulate within the placenta, inducing pathology and poor birth outcomes. Multiple exposures to placental malaria (PM) induce partial immunity against VAR2CSA, making it a promising vaccine… read more here.
Keywords: plasmodium falciparum; var2csa dbl3x; sequence; dbl3x domain ... See more keywords