Borneol-mediated vardenafil hydrochloride patch for pediatric pulmonary arterial hypertension: preparation, characterization and in vivo study.
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DOI: 10.1016/j.ijpharm.2020.119864
Abstract: BACKGROUND Pediatric pulmonary arterial hypertension (PPAH) is a malignant progressive rare disease characterized by restricted pulmonary artery blood flow and progressively increasing blood pressure, which has shorter survival time of only about 10 months as… read more here.
Keywords: varp; arterial hypertension; patch; pulmonary arterial ... See more keywords
Polyamidoamine (PAMAM) dendrimers as potential release modulators and oral bioavailability enhancers of vardenafil hydrochloride
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DOI: 10.1080/10837450.2018.1472611
Abstract: Abstract Vardenafil hydrochloride (VAR) is an erectile dysfunction treating drug. VAR has a short elimination half-life (4–5 h) and suffers low oral bioavailability (15%). This work aimed to explore the dual potential of VAR-dendrimer complexes as… read more here.
Keywords: oral bioavailability; release modulators; bioavailability; vardenafil hydrochloride ... See more keywords
Combinations of Freeze-Dried Amorphous Vardenafil Hydrochloride with Saccharides as a Way to Enhance Dissolution Rate and Permeability
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DOI: 10.3390/ph14050453
Abstract: To improve physicochemical properties of vardenafil hydrochloride (VAR), its amorphous form and combinations with excipients—hydroxypropyl methylcellulose (HPMC) and β-cyclodextrin (β-CD)—were prepared. The impact of the modification on physicochemical properties was estimated by comparing amorphous mixtures… read more here.
Keywords: amorphous var; form; permeability; vardenafil hydrochloride ... See more keywords