Efficacy and Safety of Varenicline for Adolescent Smoking Cessation: A Randomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2019 at "JAMA pediatrics"
DOI: 10.1001/jamapediatrics.2019.3553
Abstract: Importance Cigarette smoking is the leading cause of preventable morbidity and mortality in the United States and worldwide, and most tobacco users begin smoking in adolescence. Although advances have yielded efficacious pharmacotherapies to complement smoking… read more here.
Keywords: varenicline; treatment; group; abstinence ... See more keywords
Comparison of hydrodynamically closed two-dimensional capillary electrophoresis coupled with ultraviolet detection and hydrodynamically open capillary electrophoresis hyphenated with mass spectrometry in the bioanalysis of varenicline.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of separation science"
DOI: 10.1002/jssc.201700098
Abstract: Two capillary electrophoresis methods for monitoring renally excreted varenicline, a highly effective drug prescribed for smoking cessation, in human urine were developed and compared. A method combining capillary electrophoresis with mass spectrometry was proposed for… read more here.
Keywords: electrophoresis; capillary electrophoresis; varenicline; mass spectrometry ... See more keywords
Cost-effectiveness analysis of treatment with varenicline for nicotine dependence compared with smoking cessation without pharmacotherapy in the real world.
Sign Up to like & getrecommendations! Published in 2021 at "Pharmacoepidemiology and drug safety"
DOI: 10.1002/pds.5359
Abstract: PURPOSE Smoking is an important public health issue. Although measures to support smoking cessation have been implemented worldwide, smokers often fail to quit smoking after receiving pharmacotherapies for nicotine dependence. The present study evaluated the… read more here.
Keywords: varenicline; nicotine dependence; smoking cessation; cessation ... See more keywords
The effect of varenicline on mood and cognition in smokers with HIV
Sign Up to like & getrecommendations! Published in 2020 at "Psychopharmacology"
DOI: 10.1007/s00213-020-05451-w
Abstract: Rationale Barriers to smoking cessation, including negative affect and cognitive dysfunction, may contribute to high smoking rates among people living with HIV/AIDS (PLWH). Varenicline may help PLWH quit smoking by improving mood and cognition, yet… read more here.
Keywords: varenicline mood; varenicline; effect varenicline; mood cognition ... See more keywords
Varenicline for smoking reduction in smokers not yet ready to quit: A double-blind, proof-of-concept randomized clinical trial.
Sign Up to like & getrecommendations! Published in 2018 at "Addictive behaviors"
DOI: 10.1016/j.addbeh.2018.03.026
Abstract: BACKGROUND Varenicline has demonstrated efficacy for quitting smoking. Its agonist and antagonist effects suggest that it would be efficacious for reducing cigarettes per day in smokers not yet ready to quit. OBJECTIVES To conduct a… read more here.
Keywords: varenicline; quit; ready quit; proof concept ... See more keywords
Varenicline rescues nicotine-induced decrease in motivation for sucrose reinforcement
Sign Up to like & getrecommendations! Published in 2021 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2020.112887
Abstract: Varenicline is one of the top medications used for smoking cessation and is often prescribed before termination of nicotine use. The effect of this combined nicotine and varenicline use on the reward system and motivation… read more here.
Keywords: varenicline rescues; nicotine induced; varenicline; nicotine varenicline ... See more keywords
Varenicline modulates ethanol and saccharin consumption in adolescent male and female C57BL/6J mice
Sign Up to like & getrecommendations! Published in 2018 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2017.07.020
Abstract: Adolescence is a critical period in brain development that coincides with the initiation of alcohol use. Nicotinic acetylcholine receptors (nAChR) have been shown to modulate ethanol behaviors in adult humans and in animal models; however,… read more here.
Keywords: ethanol behaviors; varenicline; adolescent male; ethanol consumption ... See more keywords
Efficacy of Varenicline for Cigarette Reduction Before Quitting in Japanese Smokers: A Subpopulation Analysis of the Reduce to Quit Trial.
Sign Up to like & getrecommendations! Published in 2017 at "Clinical therapeutics"
DOI: 10.1016/j.clinthera.2017.03.007
Abstract: PURPOSE This prospective analysis of the Japanese subpopulation of the varenicline reduce to quit study was conducted to evaluate whether results for Japanese participants were consistent with the full study population. METHODS Patients received varenicline… read more here.
Keywords: reduction; reduce quit; week; varenicline ... See more keywords
Varenicline limits ischemia reperfusion injury following testicular torsion in mice.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of pediatric urology"
DOI: 10.1016/j.jpurol.2021.07.004
Abstract: BACKGROUND Torsion of the spermatic cord and the resulting testicular ischemia leads to the production of inflammatory cytokines and cell death due to impaired aerobic metabolism. Following reperfusion of the testis, a robust innate inflammatory… read more here.
Keywords: testicular torsion; torsion; following reperfusion; varenicline ... See more keywords
Determination of varenicline after photochemical fluorescence enhancement using spectrofluorimetry and high-performance liquid chromatography
Sign Up to like & getrecommendations! Published in 2019 at "Microchemical Journal"
DOI: 10.1016/j.microc.2018.09.006
Abstract: Abstract Photochemical derivatization (at 253 nm) of varenicline in alkaline medium (in NaOH 0.64 mol L−1) was successfully achieved aiming to induce strong fluorescence for quantitative purposes. The intense fluorescence from the produced photo-derivative covered a linear range… read more here.
Keywords: varenicline; performance liquid; fluorescence; liquid chromatography ... See more keywords
Specificity of Varenicline in Blocking Mesolimbic Circuit Activation to Natural and Drug Rewards
Sign Up to like & getrecommendations! Published in 2022 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2021.12.016
Abstract: The mesolimbic dopamine (DA) system reinforces behaviors that are critical for survival. However, drug dependence can occur when drugs of abuse, such as nicotine, highjack this reinforcement system. Pharmacologically targeting the DA system to selectively… read more here.
Keywords: system; drug; natural drug; specificity varenicline ... See more keywords