Structural basis for phospholipase A2-like toxin inhibition by the synthetic compound Varespladib (LY315920)
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DOI: 10.1038/s41598-019-53755-5
Abstract: The World Health Organization recently listed snakebite envenoming as a Neglected Tropical Disease, proposing strategies to significantly reduce the global burden of this complex pathology by 2030. In this context, effective adjuvant treatments to complement… read more here.
Keywords: structural basis; varespladib ly315920; varespladib; inhibition ... See more keywords
Varespladib (LY315920) and Methyl Varespladib (LY333013) Abrogate or Delay Lethality Induced by Presynaptically Acting Neurotoxic Snake Venoms
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DOI: 10.3390/toxins12020131
Abstract: The phospholipase A2 (PLA2) inhibitor Varespladib (LY315920) and its orally bioavailable prodrug, methyl-Varespladib (LY333013) inhibit PLA2 activity of a wide variety of snake venoms. In this study, the ability of these two forms of Varespladib… read more here.
Keywords: presynaptically acting; varespladib ly315920; varespladib; snake venoms ... See more keywords
In Vitro Efficacy of Antivenom and Varespladib in Neutralising Chinese Russell’s Viper (Daboia siamensis) Venom Toxicity
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DOI: 10.3390/toxins15010062
Abstract: The venom of the Russell’s viper (Daboia siamensis) contains neurotoxic and myotoxic phospholipase A2 toxins which can cause irreversible damage to motor nerve terminals. Due to the time delay between envenoming and antivenom administration, antivenoms… read more here.
Keywords: siamensis; venom; russell viper; viper daboia ... See more keywords