Structural basis for phospholipase A2-like toxin inhibition by the synthetic compound Varespladib (LY315920)
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DOI: 10.1038/s41598-019-53755-5
Abstract: The World Health Organization recently listed snakebite envenoming as a Neglected Tropical Disease, proposing strategies to significantly reduce the global burden of this complex pathology by 2030. In this context, effective adjuvant treatments to complement… read more here.
Keywords: structural basis; varespladib ly315920; varespladib; inhibition ... See more keywords
Varespladib (LY315920) and Methyl Varespladib (LY333013) Abrogate or Delay Lethality Induced by Presynaptically Acting Neurotoxic Snake Venoms
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DOI: 10.3390/toxins12020131
Abstract: The phospholipase A2 (PLA2) inhibitor Varespladib (LY315920) and its orally bioavailable prodrug, methyl-Varespladib (LY333013) inhibit PLA2 activity of a wide variety of snake venoms. In this study, the ability of these two forms of Varespladib… read more here.
Keywords: presynaptically acting; varespladib ly315920; varespladib; snake venoms ... See more keywords