Multivalent targeting and killing of HER2 overexpressing breast carcinoma cells with methotrexate‐encapsulated tetra‐specific non‐overlapping variable domain heavy chain anti‐HER2 antibody‐PEG‐liposomes: In vitro proof‐of‐concept
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2018.06.019
Abstract: &NA; The variable domain of the heavy chain antibodies (VHHs) is the smallest (15 kDa) intact single domain antigen‐binding fragment. VHHs often exhibit sub‐nanomolar affinity for their designated targets and therefore are receiving increasing attention… read more here.
Keywords: variable domain; domain heavy; her2; domain ... See more keywords
Surface Ig variable domain glycosylation affects autoantigen binding and acts as threshold for human autoreactive B cell activation
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DOI: 10.1126/sciadv.abm1759
Abstract: The hallmark autoantibodies in rheumatoid arthritis are characterized by variable domain glycans (VDGs). Their abundant occurrence results from the selective introduction of N-linked glycosylation sites during somatic hypermutation, and their presence is predictive for disease… read more here.
Keywords: cell activation; cell; glycosylation; variable domain ... See more keywords