Construction and characterization of a class-specific single-chain variable fragment against pyrethroid metabolites
Sign Up to like & getrecommendations! Published in 2020 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-020-10728-3
Abstract: Pyrethroids are insecticides that are widely used in rural and urban areas worldwide. After entering the environment, pyrethroids are rapidly metabolized or degraded by various biological or abiotic methods. In this study, a single-chain variable… read more here.
Keywords: pyrethroid metabolites; scfv; chain variable; variable fragment ... See more keywords
Single chain variable fragment antibodies directed against SOD1 ameliorate disease in mutant SOD1 transgenic mice
Sign Up to like & getrecommendations! Published in 2019 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2018.08.021
Abstract: Mutations in Cu/Zn superoxide dismutase (SOD1) are the cause of ~20% of cases of familial ALS (FALS), which comprise ~10% of the overall total number of cases of ALS. Mutant (mt) SOD1 is thought to… read more here.
Keywords: sod1; directed sod1; mutant sod1; chain variable ... See more keywords
Anti-Aβ single-chain variable fragment antibodies restore memory acquisition in a Drosophila model of Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-11594-2
Abstract: Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder triggered by the accumulation of soluble assemblies of the amyloid-β42 (Aβ42) peptide. Despite remarkable advances in understanding the pathogenesis of AD, the development of palliative therapies is… read more here.
Keywords: drosophila; alzheimer disease; disease; chain variable ... See more keywords
Development of single-chain Fv of antibody to DNA as intracellular delivery vehicle
Sign Up to like & getrecommendations! Published in 2017 at "Animal Cells and Systems"
DOI: 10.1080/19768354.2017.1401556
Abstract: ABSTRACT Application of antibodies in most therapeutic area is limited to extracellular or membranous targets because of their impermeability of membrane. For the purpose of biotechnological and therapeutic application, developing intracellular localizing antibody is the… read more here.
Keywords: chain; vehicle; antibody; chain variable ... See more keywords