Antibody variable region engineering for improving cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Communications"
DOI: 10.1002/cac2.12330
Abstract: The efficacy and specificity of conventional monoclonal antibody (mAb) drugs in the clinic require further improvement. Currently, the development and application of novel antibody formats for improving cancer immunotherapy have attracted much attention. Variable region‐retaining… read more here.
Keywords: improving cancer; variable region; engineering; cancer ... See more keywords
Sequence features of variable region determining physicochemical properties and polyreactivity of therapeutic antibodies.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular immunology"
DOI: 10.1016/j.molimm.2019.06.012
Abstract: Therapeutic antibodies have transformed the clinical practice. Not surprisingly, development of antibody therapeutics is currently the main focus of the biotechnology industry. Nonetheless, the development process is complex, and many antibodies do not reach the… read more here.
Keywords: therapeutic antibodies; features variable; polyreactivity; variable region ... See more keywords
Sequencing of the variable region of rpsB to discriminate between Streptococcus pneumoniae and other streptococcal species
Sign Up to like & getrecommendations! Published in 2017 at "Open Biology"
DOI: 10.1098/rsob.170074
Abstract: The vast majority of streptococci colonizing the human upper respiratory tract are commensals, only sporadically implicated in disease. Of these, the most pathogenic is Mitis group member, Streptococcus pneumoniae. Phenotypic and genetic similarities between streptococci… read more here.
Keywords: sequencing variable; streptococcus pneumoniae; streptococcal species; variable region ... See more keywords
Variable Region Sequences Influence 16S rRNA Performance
Sign Up to like & getrecommendations! Published in 2023 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.01252-23
Abstract: This study reevaluates the notion that 16S rRNA gene variable region sequences are uninformative for intra-genus classification and that single nucleotide variations within them have no consequence to strains that bear them. We demonstrated that… read more here.
Keywords: 16s rrna; region sequences; variable region; variable regions ... See more keywords
HIV vaccine delayed boosting increases Env variable region 2-specific antibody effector functions.
Sign Up to like & getrecommendations! Published in 2020 at "JCI insight"
DOI: 10.1172/jci.insight.131437
Abstract: In the RV144 HIV-1 phase III trial, vaccine efficacy directly correlated with the magnitude of the variable region 2-specific (V2-specific) IgG antibody response, and in the presence of low plasma IgA levels, with the magnitude… read more here.
Keywords: effector functions; hiv; antibody; region specific ... See more keywords
Characterization of Variable Region Genes and Discovery of Key Recognition Sites in the Complementarity Determining Regions of the Anti-Thiacloprid Monoclonal Antibody
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21186857
Abstract: Sequence-defined recombinant antibodies (rAbs) have emerged as alternatives to hybridoma-secreted monoclonal antibodies (mAbs) for performing immunoassays. However, the polyploidy nature of hybridomas often leads to the coexistence of aberrant or non-specific functional variable region (VR)… read more here.
Keywords: complementarity determining; antibody; determining regions; anti thiacloprid ... See more keywords
Serum Proteomic Analysis by Nanoflow LC-MS/MS-Based Proteomics in IgA Chronic Kidney Disease.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical laboratory"
DOI: 10.7754/clin.lab.2022.220417
Abstract: BACKGROUND IgA nephropathy (IgAN) is the most frequently occurring primary glomerulonephritis. A lack of specific biomarkers hinders the early diagnosis and treatment of this disease. This study analyzes and validates potential serum biomarkers using mass… read more here.
Keywords: disease; serum; variable region; chain variable ... See more keywords