Dual‐detection approach for a charge variant analysis of monoclonal antibody combination products using imaged capillary isoelectric focusing
Sign Up to like & getrecommendations! Published in 2022 at "ELECTROPHORESIS"
DOI: 10.1002/elps.202200026
Abstract: The clinical benefits of treatments with a combination of two or more therapeutic monoclonal antibodies (mAbs) have emerged in recent years. Imaged capillary isoelectric focusing is a frequently used technology in the biopharmaceutical industry for… read more here.
Keywords: charge variant; variant analysis; combination; charge ... See more keywords
Erratum: Genome-wide common and rare variant analysis provides novel insights into clozapine-associated neutropenia
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Psychiatry"
DOI: 10.1038/mp.2017.214
Abstract: This corrects the article DOI: 10.1038/mp.2016.97 read more here.
Keywords: genome wide; wide common; variant analysis; common rare ... See more keywords
Plasma cell-free DNA variant analysis compared with methylated DNA analysis in renal cell carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Genetics in Medicine"
DOI: 10.1038/s41436-020-0801-x
Abstract: Purpose Plasma cell-free DNA (cfDNA) variant analysis is commonly used in many cancer subtypes. Cell-free methylated DNA immunoprecipitation sequencing (cfMeDIP-seq) has shown high sensitivity for cancer detection. To date, studies have not compared the sensitivity… read more here.
Keywords: variant analysis; analysis; cfmedip seq; cell free ... See more keywords
Comprehensive RAD51C ovarian cancer variant analysis uncouples homologous recombination and replicative functions
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DOI: 10.1038/s41467-025-61283-2
Abstract: RAD51C is a tumor suppressor gene with over 285 variants of unknown significance (VUS) found in primary ovarian tumors. RAD51C is a paralog of the recombinase RAD51, and it forms complexes with other paralogs to… read more here.
Keywords: analysis; variant analysis; ovarian cancer; homologous recombination ... See more keywords
Assessment of the functionality and usability of open-source rare variant analysis pipelines
Sign Up to like & getrecommendations! Published in 2024 at "Briefings in Bioinformatics"
DOI: 10.1093/bib/bbaf044
Abstract: Abstract Sequencing of increasingly larger cohorts has revealed many rare variants, presenting an opportunity to further unravel the genetic basis of complex traits. Compared with common variants, rare variants are more complex to analyze. Specialized… read more here.
Keywords: source rare; open source; analysis; variant analysis ... See more keywords
Insights on variant analysis in silico tools for pathogenicity prediction
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.1010327
Abstract: Molecular biology is currently a fast-advancing science. Sequencing techniques are getting cheaper, but the interpretation of genetic variants requires expertise and computational power, therefore is still a challenge. Next-generation sequencing releases thousands of variants and… read more here.
Keywords: insights variant; pathogenicity prediction; variant analysis;
Variant Analysis of SARS-CoV-2 Genomes from Belgian Military Personnel Engaged in Overseas Missions and Operations
Sign Up to like & getrecommendations! Published in 2021 at "Viruses"
DOI: 10.3390/v13071359
Abstract: More than a year after the first identification of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as the causative agent of the 2019 coronavirus disease (COVID-19) in China, the emergence and spread of genomic variants… read more here.
Keywords: variant analysis; military personnel; missions operations; belgian military ... See more keywords