Histone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms14995
Abstract: The senescence of mammalian cells is characterized by a proliferative arrest in response to stress and the expression of an inflammatory phenotype. Here we show that histone H2A.J, a poorly studied H2A variant found only… read more here.
Keywords: variant h2a; senescent cells; h2a; expression ... See more keywords
Histone variant H2A.Z regulates nucleosome unwrapping and CTCF binding in mouse ES cells
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa360
Abstract: Abstract Nucleosome is the basic structural unit of chromatin, and its dynamics plays critical roles in the regulation of genome functions. However, how the nucleosome structure is regulated by histone variants in vivo is still… read more here.
Keywords: variant h2a; h2a nucleosomes; ctcf binding; h2a ... See more keywords
Structural basis of chromatin regulation by histone variant H2A.Z.
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic acids research"
DOI: 10.1093/nar/gkab907
Abstract: The importance of histone variant H2A.Z in transcription regulation has been well established, yet its mechanism-of-action remains enigmatic. Conflicting evidence exists in support of both an activating and a repressive role of H2A.Z in transcription.… read more here.
Keywords: variant h2a; chromatin regulation; h2a; histone variant ... See more keywords
The Histone Variant H2A.Z C-Terminal Domain Has Locus-Specific Differential Effects on H2A.Z Occupancy and Nucleosome Localization
Sign Up to like & getrecommendations! Published in 2023 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.02550-22
Abstract: We provide evidence that the Saccharomyces cerevisiae C-terminal region of histone variant H2A.Z can mediate its special function in performing gene regulation by interacting with effector proteins and chaperones. These functional interactions allow H2A.Z not… read more here.
Keywords: terminal region; region; h2a; variant h2a ... See more keywords