MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA.
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DOI: 10.1038/s41467-021-27062-5
Abstract: Our innate immune responses to viral RNA are vital defenses. Long cytosolic double-stranded RNA (dsRNA) is recognized by MDA5. The ATPase activity of MDA5 contributes to its dsRNA binding selectivity. Mutations that reduce RNA selectivity… read more here.
Keywords: variant m854k; rna; atp dependent; disease ... See more keywords