Histone Variant macroH2A1.1 Enhances Nonhomologous End Joining-dependent DNA Double-strand-break Repair and Reprogramming Efficiency of Human iPSCs.
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DOI: 10.1093/stmcls/sxab004
Abstract: DNA damage repair (DDR) is a safeguard for genome integrity maintenance. Increasing DDR efficiency could increase the yield of induced pluripotent stem cells (iPSC) upon reprogramming from somatic cells. The epigenetic mechanisms governing DDR during… read more here.
Keywords: variant macroh2a1; macroh2a1; repair; macroh2a1 macroh2a1 ... See more keywords
The histone variant macroH2A1.1 regulates RNA polymerase II-paused genes within defined chromatin interaction landscapes
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DOI: 10.1242/jcs.259456
Abstract: ABSTRACT The histone variant macroH2A1.1 plays a role in cancer development and metastasis. To determine the underlying molecular mechanisms, we mapped the genome-wide localization of endogenous macroH2A1.1 in the human breast cancer cell line MDA-MB-231.… read more here.
Keywords: variant macroh2a1; paused genes; macroh2a1; rna polymerase ... See more keywords