Variant screening of PYY3-36 leads to potent long-acting PYY analogs with superior Y2 receptor selectivity.
Sign Up to like & getrecommendations! Published in 2025 at "Science translational medicine"
DOI: 10.1126/scitranslmed.adq6392
Abstract: Peptide YY (PYY3-36) has attracted attention in diabetes and obesity research because of its involvement in food intake regulation and glucose homeostasis. Native PYY3-36 maintains high potency on the Y2 receptor with a loss of… read more here.
Keywords: receptor; screening pyy3; long acting; variant screening ... See more keywords
A Human TSC1 Variant Screening Platform in Gabaergic Cortical Interneurons for Genotype to Phenotype Assessments
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2020.573409
Abstract: The TSC1 and TSC2 genes are connected to multiple syndromes from Tuberous Sclerosis Complex (TSC) to autism spectrum disorder (ASD), with uncertainty if genetic variants cause all or subsets of phenotypes based on the location… read more here.
Keywords: tsc1; genotype phenotype; human tsc1; variant screening ... See more keywords