Evolution of the variant surface glycoprotein family in African trypanosomes.
Sign Up to like & getrecommendations! Published in 2021 at "Trends in parasitology"
DOI: 10.1016/j.pt.2021.07.012
Abstract: An intriguing and remarkable feature of African trypanosomes is their antigenic variation system, mediated by the variant surface glycoprotein (VSG) family and fundamental to both immune evasion and disease epidemiology within host populations. Recent studies… read more here.
Keywords: surface glycoprotein; variant surface; family; evolution variant ... See more keywords
Identification of potential protein partners that bind to the variant surface glycoprotein in Trypanosoma equiperdum
Sign Up to like & getrecommendations! Published in 2017 at "Parasitology"
DOI: 10.1017/s003118201700004x
Abstract: SUMMARY Trypanosoma equiperdum possesses a dense coat of a variant surface glycoprotein (VSG) that is used to evade the host immune response by a process known as antigenic variation. Soluble and membrane forms of the… read more here.
Keywords: protein; vsg; trypanosoma equiperdum; surface ... See more keywords
Monoallelic expression and epigenetic inheritance sustained by a Trypanosoma brucei variant surface glycoprotein exclusion complex
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-10823-8
Abstract: The largest gene families in eukaryotes are subject to allelic exclusion, but mechanisms underpinning single allele selection and inheritance remain unclear. Here, we describe a protein complex sustaining variant surface glycoprotein (VSG) allelic exclusion and… read more here.
Keywords: surface glycoprotein; exclusion; inheritance; variant surface ... See more keywords
Structural basis for the shielding function of the dynamic trypanosome variant surface glycoprotein coat
Sign Up to like & getrecommendations! Published in 2017 at "Nature Microbiology"
DOI: 10.1038/s41564-017-0013-6
Abstract: The most prominent defence of the unicellular parasite Trypanosoma brucei against the host immune system is a dense coat that comprises a variant surface glycoprotein (VSG). Despite the importance of the VSG family, no complete… read more here.
Keywords: vsg; surface glycoprotein; surface; variant surface ... See more keywords
Beyond immune escape: a variant surface glycoprotein causes suramin resistance in Trypanosoma brucei
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Microbiology"
DOI: 10.1111/mmi.13854
Abstract: Suramin is one of the first drugs developed in a medicinal chemistry program (Bayer, 1916), and it is still the treatment of choice for the hemolymphatic stage of African sleeping sickness caused by Trypanosoma brucei… read more here.
Keywords: surface glycoprotein; variant surface; trypanosoma brucei; suramin resistance ... See more keywords
Transcription Dependent Loss of an Ectopically Expressed Variant Surface Glycoprotein during Antigenic Variation in Trypanosoma brucei
Sign Up to like & getrecommendations! Published in 2022 at "mBio"
DOI: 10.1128/mbio.03847-21
Abstract: The single-cell parasite Trypanosoma brucei causes the fatal disease human African trypanosomiasis and is able to colonize the blood, fat, skin, and central nervous system. Trypanosomes survive in the mammalian host owing to a dense… read more here.
Keywords: variant surface; surface glycoprotein; trypanosoma brucei; vsg ... See more keywords
Turnover of Variant Surface Glycoprotein in Trypanosoma brucei Is Not Altered in Response to Specific Silencing
Sign Up to like & getrecommendations! Published in 2022 at "mSphere"
DOI: 10.1128/msphere.00122-22
Abstract: African trypanosomes evade the host immune system by altering the expression of variant surface glycoproteins (VSGs) in a process called antigenic variation. VSG is essential, and when its synthesis is ablated by RNAi silencing, cells… read more here.
Keywords: cell surface; surface; vsg; turnover ... See more keywords