Cataract-prone variants of γD-crystallin populate a conformation with a partially unfolded N-terminal domain under native conditions
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DOI: 10.1073/pnas.2410860122
Abstract: Human γD-crystallin, a monomeric protein abundant in the eye lens nucleus, must remain stably folded for an individual’s entire lifetime to avoid aggregation and protein deposition-associated cataract formation. γD-crystallin contains two homologous domains, an N-terminal… read more here.
Keywords: terminal domain; protein; variants crystallin; native conditions ... See more keywords