Genetic associations at regulatory phenotypes improve fine-mapping of causal variants for 12 immune-mediated diseases.
Sign Up to like & getrecommendations! Published in 2022 at "Nature genetics"
DOI: 10.1038/s41588-022-01025-y
Abstract: The resolution of causal genetic variants informs understanding of disease biology. We used regulatory quantitative trait loci (QTLs) from the BLUEPRINT, GTEx and eQTLGen projects to fine-map putative causal variants for 12 immune-mediated diseases. We… read more here.
Keywords: causal variants; fine mapping; variants immune; disease ... See more keywords
Identifying Rare Genetic Variants of Immune Mediators as Risk Factors for Autism Spectrum Disorder
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13061098
Abstract: Autism spectrum disorder (ASD) affects more than 1% of children, and there is no viable pharmacotherapeutic agent to treat the core symptoms of ASD. Studies have shown that children with ASD show changes in their… read more here.
Keywords: genetic variants; variants immune; autism spectrum; immune mediators ... See more keywords