All ion differential analysis refines the detection of terminal and internal diagnostic fragment ions for the characterization of biologics product-related variants and impurities by middle-down mass spectrometry.
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DOI: 10.1021/acs.analchem.8b05886
Abstract: Characterization and monitoring of post-translational modifications (PTMs) are key analytical requirements during the development of biologics. Top and middle-down (MD) approaches aim at capturing a direct snapshot of all proteoforms with their combinatorial distribution. However,… read more here.
Keywords: methodology; differential analysis; analysis; variants impurities ... See more keywords