Intergenic variants may predispose to major depression disorder through regulation of long non-coding RNA expression.
Sign Up to like & getrecommendations! Published in 2017 at "Gene"
DOI: 10.1016/j.gene.2016.11.041
Abstract: Genome-wide association (GWA) studies have identified numerous genetic variants for major depressive disorder (MDD) although most of the genetic variants are intergenic. It has been found that approximately 54% of long non-coding RNAs (lncRNAs) are… read more here.
Keywords: disorder; long non; variants may; non coding ... See more keywords
Novel compound heterozygous EYS variants may be associated with arRP in a large Chinese pedigree
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DOI: 10.1042/bsr20193443
Abstract: Abstract As a genetically heterogeneous ocular dystrophy, gene mutations with autosomal recessive retinitis pigmentosa (arRP) in patients have not been well described. We aimed to detect the disease-causing genes and variants in a Chinese arRP… read more here.
Keywords: novel compound; compound heterozygous; large chinese; gene ... See more keywords
APOL1 variants may induce HIV-associated nephropathy during HIV primary infection
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkw563
Abstract: HIV-associated nephropathy (HIVAN) is still associated with high mortality, and is usually a late complication of HIV chronic infection. Since 2010, a link has been strongly established between APOL1 genetic variants and HIVAN, especially in… read more here.
Keywords: associated nephropathy; hiv; infection; variants may ... See more keywords