Total Chemical Synthesis and Folding of All-l and All-d Variants of Oncogenic KRas(G12V).
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DOI: 10.1021/jacs.7b02988
Abstract: The Ras proteins are essential GTPases involved in the regulation of cell proliferation and survival. Mutated oncogenic forms of Ras alter effector binding and innate GTPase activity, leading to deregulation of downstream signal transduction. Mutated… read more here.
Keywords: total chemical; variants oncogenic; oncogenic kras; chemical synthesis ... See more keywords