Gene-enhancer variants reveal diverse TCR-mediated differentiation
Sign Up to like & getrecommendations! Published in 2017 at "Nature Immunology"
DOI: 10.1038/ni.3729
Abstract: The transcription factor IRF4 acts as a 'rheostat' for TCR signaling. Discrete levels of IRF4 can activate distinct transcriptional programs in T cells due to binding sites of variable affinity in groups of target genes. read more here.
Keywords: gene enhancer; tcr mediated; diverse tcr; enhancer variants ... See more keywords
Genomic variants reveal differential evolutionary constraints on human transglutaminases and point towards unrecognized significance of transglutaminase 2
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DOI: 10.1371/journal.pone.0172189
Abstract: Transglutaminases (TGMs) catalyze Ca2+-dependent transamidation of proteins with specified roles in blood clotting (F13a) and in cornification (TGM1, TGM3). The ubiquitous TGM2 has well described enzymatic and non-enzymatic functions but in-spite of numerous studies its… read more here.
Keywords: reveal differential; tgm2; human transglutaminases; genomic variants ... See more keywords
Single-amino acid variants reveal evolutionary processes that shape the biogeography of a global SAR11 subclade
Sign Up to like & getrecommendations! Published in 2019 at "eLife"
DOI: 10.7554/elife.46497
Abstract: Members of the SAR11 order Pelagibacterales dominate the surface oceans. Their extensive diversity challenges emerging operational boundaries defined for microbial 'species' and complicates efforts of population genetics to study their evolution. Here, we employed single-amino… read more here.
Keywords: acid variants; amino acid; single amino; variants reveal ... See more keywords