Genetic variants in R-Spondin/RNF43 complex and gene expression levels to predict efficacy of cetuximab (cet) in patients (pts) with metastatic colorectal cancer (mCRC): Data from the FIRE-3 phase III trial.
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DOI: 10.1200/jco.2020.38.4_suppl.190
Abstract: 190Background: Wnt signaling deregulation is a primary driver of colorectal carcinogenesis. RNF43 is a key suppressor of Wnt activation while R-Spodin inhibits RNF43 activity. RNF43 mutations are a... read more here.
Keywords: complex gene; rnf43 complex; variants spondin; genetic variants ... See more keywords