Borneol-mediated vardenafil hydrochloride patch for pediatric pulmonary arterial hypertension: preparation, characterization and in vivo study.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2020.119864
Abstract: BACKGROUND Pediatric pulmonary arterial hypertension (PPAH) is a malignant progressive rare disease characterized by restricted pulmonary artery blood flow and progressively increasing blood pressure, which has shorter survival time of only about 10 months as… read more here.
Keywords: varp; arterial hypertension; patch; pulmonary arterial ... See more keywords
Mechanism and evolution of the Zn-fingernail required for interaction of VARP with VPS29
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DOI: 10.1038/s41467-020-18773-2
Abstract: VARP and TBC1D5 are accessory/regulatory proteins of retromer-mediated retrograde trafficking from endosomes. Using an NMR/X-ray approach, we determined the structure of the complex between retromer subunit VPS29 and a 12 residue, four-cysteine/Zn++ microdomain, which we… read more here.
Keywords: varp; varp tbc1d5; mechanism evolution; fingernail ... See more keywords