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Published in 2020 at "Stem cell research"
DOI: 10.1016/j.scr.2020.101849
Abstract: The Wnt pathway co-receptor, Leucine Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5), labels tumor-prone stem cell populations in certain types of tissue. In this study, we show that ARID1A and PIK3CA mutations in LGR5+…
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Keywords:
vasa recta;
endothelial progenitor;
progenitor cells;
kidney ... See more keywords
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Published in 2018 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.2017090962
Abstract: Urinary concentrating ability is central to mammalian water balance and depends on a medullary osmotic gradient generated by a countercurrent multiplication mechanism. Medullary hyperosmolarity is protected from washout by countercurrent exchange and efficient removal of…
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Keywords:
angiopoietin tie2;
fluid;
ascending vasa;
angiopoietin ... See more keywords
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Published in 2017 at "Clinical hemorheology and microcirculation"
DOI: 10.3233/ch-179230
Abstract: BACKGROUND Descending vasa recta (DVR) supply the inner part of outer renal medulla an area at risk for hypoxic damages. OBJECTIVE We hypothesize increased vasoreactivity after hypoxia/re-oxygenation (H/R) in DVR, which might contribute to the…
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Keywords:
hypoxia;
vasa recta;
dvr;
kidney slices ... See more keywords
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Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23137016
Abstract: Reduced renal medullary oxygen supply is a key factor in the pathogenesis of acute kidney injury (AKI). As the medulla exclusively receives blood through descending vasa recta (DVR), dilating these microvessels after AKI may help…
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Keywords:
descending vasa;
oxygenation;
nitric oxide;
hypoxia ... See more keywords