Mechanobiological Adaptation to Hyperosmolarity Enhances Barrier Function in Human Vascular Microphysiological System (Adv. Sci. 13/2023)
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DOI: 10.1002/advs.202206384
Abstract: In infectious disease such as sepsis and COVID‐19, blood vessel leakage treatment is critical to prevent fatal progression into multi‐organ failure and ultimately death, but the existing effective therapeutic modalities that improve vascular barrier function… read more here.
Keywords: barrier function; human vascular; function; vascular microphysiological ... See more keywords
Hypoxia‐induced disruption of neural vascular barrier is mediated by the intracellular induction of Fe(II) ion
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DOI: 10.1016/j.yexcr.2019.04.003
Abstract: &NA; Neural vascular barrier maintains the optimal tissue microenvironment of central nervous system in which neural cells can function normally. In various neural diseases, the decrease in oxygen concentration, hypoxia, of affected tissues is known… read more here.
Keywords: vascular barrier; ion; neural vascular; disruption neural ... See more keywords
Passing the Vascular Barrier: Endothelial Signaling Processes Controlling Extravasation.
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DOI: 10.1152/physrev.00037.2018
Abstract: A central function of the vascular endothelium is to serve as a barrier between the blood and the surrounding tissue of the body. At the same time, solutes and cells have to pass the endothelium… read more here.
Keywords: barrier; barrier endothelial; endothelial signaling; solutes cells ... See more keywords
DOCK4 Regulation of Rho GTPases Mediates Pulmonary Vascular Barrier Function
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DOI: 10.1161/atvbaha.122.317565
Abstract: Background: The vascular endothelium maintains tissue-fluid homeostasis by controlling the passage of large molecules and fluid between the blood and interstitial space. The interaction of catenins and the actin cytoskeleton with VE-cadherin (vascular endothelial cadherin)… read more here.
Keywords: barrier function; function; permeability; dock4 ... See more keywords
The protective effect of pericytes on vascular permeability after hemorrhagic shock and their relationship with Cx43
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DOI: 10.3389/fphys.2022.948541
Abstract: Vascular hyperpermeability is a complication of hemorrhagic shock. Pericytes (PCs) are a group of mural cells surrounded by microvessels that are located on the basolateral side of the endothelium. Previous studies have shown that damage… read more here.
Keywords: barrier function; cx43; hemorrhagic shock; shock ... See more keywords
Molecular Cross-Talk between Integrins and Cadherins Leads to a Loss of Vascular Barrier Integrity during SARS-CoV-2 Infection
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DOI: 10.3390/v14050891
Abstract: The vascular barrier is heavily injured following SARS-CoV-2 infection and contributes enormously to life-threatening complications in COVID-19. This endothelial dysfunction is associated with the phlogistic phenomenon of cytokine storms, thrombotic complications, abnormal coagulation, hypoxemia, and… read more here.
Keywords: barrier; sars cov; molecular cross; cov infection ... See more keywords
Protocadherin gamma C3: a new player in regulating vascular barrier function
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DOI: 10.4103/1673-5374.343896
Abstract: Defects in the endothelial cell barrier accompany diverse malfunctions of the central nervous system such as neurodegenerative diseases, stroke, traumatic brain injury, and systemic diseases such as sepsis, viral and bacterial infections, and cancer. Compromised… read more here.
Keywords: barrier function; protocadherin gamma; barrier; brain ... See more keywords