Metformin protects against vascular calcification through the selective degradation of Runx2 by the p62 autophagy receptor
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30887
Abstract: Vascular calcification is associated with aging, type 2 diabetes, and atherosclerosis, and increases the risk of cardiovascular morbidity and mortality. It is an active, highly regulated process that resembles physiological bone formation. It has previously… read more here.
Keywords: calcification; vascular calcification; degradation; metformin ... See more keywords
Vascular Calcification Regulation by Exosomes in the Vascular Wall.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-10-4397-0_10
Abstract: Vascular calcification is a tightly regulated process that increases during ageing and occurs mainly in patients with diabetes and chronic renal failure. Exosomes are small membrane vesicles that are synthesized in a particular population of… read more here.
Keywords: vascular calcification; vascular wall; calcification regulation; calcification ... See more keywords
Signaling pathways involved in vascular smooth muscle cell calcification during hyperphosphatemia
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-019-03054-z
Abstract: Medial vascular calcification has emerged as a putative key factor contributing to the excessive cardiovascular mortality of patients with chronic kidney disease (CKD). Hyperphosphatemia is considered a decisive determinant of vascular calcification in CKD. A… read more here.
Keywords: signaling pathways; vascular calcification; vascular smooth; calcification ... See more keywords
The Role of Osteoprotegerin in Vascular Calcification and Bone Metabolism: The Basis for Developing New Therapeutics
Sign Up to like & getrecommendations! Published in 2019 at "Calcified Tissue International"
DOI: 10.1007/s00223-019-00573-6
Abstract: Osteoporosis (OP) and cardiovascular diseases (CVD) are both important causes of mortality and morbidity in aging patients. There are common mechanisms underlying the regulation of bone remodeling and the development of smooth muscle calcification; a… read more here.
Keywords: opg; vascular calcification; metabolism; calcification ... See more keywords
Involvement of Bone Marrow Multipotent Stromal Cells in the Processes Presumably Provoking Vascular Calcification
Sign Up to like & getrecommendations! Published in 2020 at "Bulletin of Experimental Biology and Medicine"
DOI: 10.1007/s10517-020-04735-7
Abstract: During serial transplantation of bone marrow derived from young and aged donor CBA mice to 5-month-old recipients, the counts of multipotent stromal cells (MSC) in transplants from young donors assessed at each passage surpassed those… read more here.
Keywords: vascular calcification; stromal cells; bone; msc ... See more keywords
The Role of NLRP3 Inflammasome Activities in Bone Diseases and Vascular Calcification
Sign Up to like & getrecommendations! Published in 2020 at "Inflammation"
DOI: 10.1007/s10753-020-01357-z
Abstract: Continuous stimulation of inflammation is harmful to tissues of an organism. Inflammatory mediators not only have an effect on metabolic and inflammatory bone diseases but also have an adverse effect on certain genetic and periodontal… read more here.
Keywords: vascular calcification; calcification; bone diseases; nlrp3 inflammasome ... See more keywords
Overexpression of HOTAIR attenuates Pi-induced vascular calcification by inhibiting Wnt/β-catenin through regulating miR-126/Klotho/SIRT1 axis.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular and cellular biochemistry"
DOI: 10.1007/s11010-021-04164-8
Abstract: Vascular calcification is one of the most common effects of macrovascular complications in patients in aging with chronic kidney disease and diabetes. Previous studies showed that HOTAIR attenuated vascular calcification via the Wnt/β-catenin-signaling pathway, yet… read more here.
Keywords: vascular calcification; mir 126; hotair; calcification ... See more keywords
Development, establishment and validation of in vitro and ex vivo assays of vascular calcification.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.05.085
Abstract: OBJECTIVE Vascular calcification (VC) is one major complication in patients with chronic kidney disease, with a misbalance in calcium and phosphate metabolism playing crucial role. The mechanisms underlying VC have not been entirely revealed to… read more here.
Keywords: establishment validation; vascular calcification; vitro vivo; development establishment ... See more keywords
Metformin, resveratrol, and exendin-4 inhibit high phosphate-induced vascular calcification via AMPK-RANKL signaling.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.07.136
Abstract: Vascular calcification increases the risk of developing cardiovascular disease, and it is closely associated with metabolic disorders such as diabetes mellitus and non-alcoholic fatty liver disease. We investigated whether the activators of AMP-activated protein kinase… read more here.
Keywords: resveratrol exendin; metformin resveratrol; vascular calcification;
The role of bone morphogenetic protein signaling in vascular calcification.
Sign Up to like & getrecommendations! Published in 2020 at "Bone"
DOI: 10.1016/j.bone.2020.115542
Abstract: Vascular calcification is associated with atherosclerosis, chronic kidney disease, and diabetes, and results from processes resembling endochondral or intramembranous ossification, or from processes that are distinct from ossification. Bone morphogenetic proteins (BMP), as well as… read more here.
Keywords: protein; bmp signaling; vascular calcification; calcification ... See more keywords
POSTN promotes diabetic vascular calcification by interfering with autophagic flux.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2021.109983
Abstract: Autophagy is a lysosomal degradative process that is closely related to the pathogenesis of vascular calcification. Recent evidence suggests that periostin (POSTN) is a unique extracellular matrix protein that is associated with diabetic vascular complications.… read more here.
Keywords: diabetic vascular; vascular calcification; postn; calcification ... See more keywords