Amyloid-beta peptide potentiates vascular Cav1.2 channel activity
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DOI: 10.1152/physiol.2023.38.s1.5727832
Abstract: Alzheimer’s disease (AD), the most common form of dementia, affects over 6 million Americans and has devastating emotional and physical consequences for both the patient and surrounding loved ones. Current drug therapies are principally targeted… read more here.
Keywords: physiology; vascular cav1; channel activity; cav1 channel ... See more keywords
Oxidative Regulation of Vascular Cav1.2 Channels Triggers Vascular Dysfunction in Hypertension-Related Disorders
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DOI: 10.3390/antiox11122432
Abstract: Blood pressure is determined by cardiac output and peripheral vascular resistance. The L-type voltage-gated Ca2+ (Cav1.2) channel in small arteries and arterioles plays an essential role in regulating Ca2+ influx, vascular resistance, and blood pressure.… read more here.
Keywords: vascular dysfunction; hypertension; dysfunction; vascular cav1 ... See more keywords