Genetic Deficiency of MicroRNA-15a/16-1 Confers Resistance to Neuropathological Damage and Cognitive Dysfunction in Experimental Vascular Cognitive Impairment and Dementia.
Sign Up to like & getrecommendations! Published in 2022 at "Advanced science"
DOI: 10.1002/advs.202104986
Abstract: Chronic cerebral hypoperfusion-derived brain damage contributes to the progression of vascular cognitive impairment and dementia (VCID). Cumulative evidence has shown that microRNAs (miRs) are emerging as novel therapeutic targets for CNS disorders. In this study,… read more here.
Keywords: impairment dementia; vcid; damage; vascular cognitive ... See more keywords
Benefits of physical exercise on cognition and glial white matter pathology in a mouse model of vascular cognitive impairment and dementia
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DOI: 10.1002/glia.23815
Abstract: White matter (WM) pathology is a clinically predictive feature of vascular cognitive impairment and dementia (VCID). Mice overexpressing transforming growth factor‐β1 (TGF) with an underlying cerebrovascular pathology when fed a high cholesterol diet (HCD) develop… read more here.
Keywords: vcid mice; matter pathology; pathology; vascular cognitive ... See more keywords
The Brief Memory and Executive Test (BMET): A cognitive screening tool to detect and differentiate vascular cognitive impairment and Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Geriatric Psychiatry"
DOI: 10.1002/gps.4787
Abstract: While there are several cognitive screening tests available for the detection of cortical dementias such as Alzheimer's disease (AD), these are rarely designed to be sensitive to vascular cognitive impairment (VCI). The Brief Memory and… read more here.
Keywords: cognitive screening; brief memory; alzheimer disease; vascular cognitive ... See more keywords
Clinical utility of the months backward test in patients with vascular cognitive impairment
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DOI: 10.1007/s10072-020-04734-6
Abstract: Dear Editor-in-Chief, Vascular cognitive impairment (VCI) constitutes the prodromal stage of vascular dementia (VaD) with high rate of prevalence in individuals aged 65 to 80 years [1]. Research has demonstrated that the most common cause… read more here.
Keywords: patients vci; backward test; vascular cognitive; cognitive impairment ... See more keywords
Genetic knockout of myosin light chain kinase (MLCK210) prevents cerebral microhemorrhages and attenuates neuroinflammation in a mouse model of vascular cognitive impairment and dementia
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DOI: 10.1007/s11357-019-00072-4
Abstract: The blood-brain barrier (BBB) is critical in maintenance of brain homeostasis, and loss of its functional integrity is a key feature across a broad range of neurological insults. This includes both acute injuries such as… read more here.
Keywords: myosin light; neuroinflammation; vascular cognitive; cognitive impairment ... See more keywords
Therapeutic and Diagnostic Potential of microRNAs in Vascular Cognitive Impairment
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-020-01597-6
Abstract: Vascular cognitive impairment (VCI) is the second most common type of dementia that accounts for 15 to 30%. To date, VCI still lacks an effective therapeutic strategy and an objective diagnostic tool. MicroRNAs (miRNAs) are… read more here.
Keywords: diagnostic potential; vascular cognitive; cognitive impairment; potential micrornas ... See more keywords
Soluble Epoxide Hydrolase-Derived Linoleic Acid Oxylipins in Serum Are Associated with Periventricular White Matter Hyperintensities and Vascular Cognitive Impairment
Sign Up to like & getrecommendations! Published in 2018 at "Translational Stroke Research"
DOI: 10.1007/s12975-018-0672-5
Abstract: White matter hyperintensities (WMH) are presumed to indicate subcortical ischemic vascular disease but their underlying pathobiology remains incompletely understood. The soluble epoxide hydrolase (sEH) enzyme converts anti-inflammatory and vasoactive cytochrome p450-derived polyunsaturated fatty acid epoxides… read more here.
Keywords: cognitive impairment; vascular cognitive; seh; white matter ... See more keywords
The validity of the Montreal cognitive assessment (MoCA) for the screening of vascular cognitive impairment after ischemic stroke
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DOI: 10.1007/s13760-020-01330-5
Abstract: Vascular cognitive impairment (VCI) is a common feature of vascular brain lesions. The heterogeneity of clinical presentation after a stroke makes it challenging to find. However, the Montreal Cognitive Assessment Scale (MoCA) may be suitable… read more here.
Keywords: ischemic stroke; vascular cognitive; moca; cognitive impairment ... See more keywords
Vascular Cognitive Impairment and Dementia: JACC Scientific Expert Panel.
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DOI: 10.1016/j.jacc.2019.04.034
Abstract: Cognitive impairment associated with aging has emerged as one of the major public health challenges of our time. Although Alzheimer's disease is the leading cause of clinically diagnosed dementia in Western countries, cognitive impairment of… read more here.
Keywords: vascular cognitive; cognitive impairment; impairment; impairment dementia ... See more keywords
The Role of S100B in Aerobic Training Efficacy in Older Adults with Mild Vascular Cognitive Impairment: Secondary Analysis of a Randomized Controlled Trial
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DOI: 10.1016/j.neuroscience.2019.04.052
Abstract: Aerobic training improves cognitive and brain outcomes across different populations and neurocognitive disorders of aging, including mild subcortical ischemic vascular cognitive impairment (SIVCI). However, little is known of the underlying mechanisms through which aerobic training… read more here.
Keywords: trial; adults mild; training; vascular cognitive ... See more keywords
Vascular cognitive impairment
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Disease Primers"
DOI: 10.1038/nrdp.2018.4
Abstract: The risk factors for vascular cognitive impairment (VCI) which include demographic factors, lifestyle factors and the presence of some chronic disorders, are the focus of this PrimeView, which accompanies the Primer on VCI by van… read more here.
Keywords: cognitive impairment; vascular cognitive;