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Published in 2020 at "Journal of biophotonics"
DOI: 10.1002/jbio.202000209
Abstract: Vascular disrupting agents disrupt tumour vessels, blocking the nutritional and oxygen supply tumours need to thrive. This is achieved by damaging the endothelium lining of blood vessels, resulting in red blood cells (RBCs) entering the…
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Keywords:
treatment;
vascular disrupting;
imaging;
cancer treatments ... See more keywords
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Published in 2017 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2017.05.053
Abstract: In the synergistic treatment with cytotoxic drug and vascular disrupting agent, the order of drug release shows great importance to enhance the antitumor efficacy. When vascular disrupting agent is firstly administrated, the reduced blood supply…
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Keywords:
disrupting agent;
hydrogel;
delivery;
vascular disrupting ... See more keywords
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Published in 2018 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.01.016
Abstract: Multidrug resistance (MDR) mediated by ATP-binding cassette (ABC) transporters is the major obstacle for chemotherapeutic success. Although attempts have been made to circumvent ABC transporter-mediated MDR in past decades, there is still no effective agent…
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Keywords:
agent;
disrupting agent;
vascular disrupting;
multidrug resistance ... See more keywords
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Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.01.058
Abstract: A series of twenty-six carbamates derived from aminocombretastatin A-4 (AmCA-4) were synthesized and evaluated for their capacity to affect cell proliferation, tubulin polymerization, mitotic cell arrest, microtubule network organization, apoptosis and endothelial tubular structures in vitro.…
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Keywords:
derived aminocombretastatin;
disrupting agents;
vascular disrupting;
carbamates derived ... See more keywords
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Published in 2017 at "Journal of Controlled Release"
DOI: 10.1016/j.jconrel.2017.10.006
Abstract: &NA; Anti‐angiogenic and vascular disrupting therapies rely on the dependence of tumors on new blood vessels to sustain tumor growth. We previously reported a potent vascular disrupting agent, a theranostic nanosystem consisting of a tumor…
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Keywords:
changes tumors;
resistant vascular;
treatment;
vascular disrupting ... See more keywords
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Published in 2021 at "Genetics"
DOI: 10.1093/genetics/iyab101
Abstract: Thiabendazole (TBZ) is an FDA-approved benzimidazole widely used for its antifungal and antihelminthic properties. We showed previously that TBZ is also a potent vascular disrupting agent and inhibits angiogenesis at the tissue level by dissociating…
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Keywords:
pesticide resistance;
vascular disrupting;
action;
humanized yeast ... See more keywords
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Published in 2022 at "Cancers"
DOI: 10.3390/cancers14174208
Abstract: Simple Summary Vascular-disrupting agents promise significant therapeutic efficacy against solid tumors by selectively damaging tumor-associated vasculature. Following administration of the phosphate prodrug OXi6197, dynamic bioluminescence imaging revealed dose-responsive vascular shutdown in MDA-MB-231 human breast tumor…
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Keywords:
disrupting activity;
prodrug oxi6197;
mda 231;
vascular disrupting ... See more keywords
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Published in 2022 at "Cancers"
DOI: 10.3390/cancers14235826
Abstract: Simple Summary The role of the blood–brain barrier in intracranial cancer treatment by vascular-disrupting agents remains unclear. Intraindividual comparison of vascular shutdown by a craniofacial metastasis model was performed, on the basis of in vivo…
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Keywords:
extracranial tumors;
barrier;
multiparametric mri;
pathology ... See more keywords
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Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21134778
Abstract: Immune therapy improves cancer outcomes, yet many patients do not respond. This pre-clinical study investigated whether vascular disrupting agents (VDAs) could convert an immune unresponsive tumor into a responder. CDF1 mice, with 200 mm3 C3H…
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Keywords:
anti ctla;
checkpoint inhibitors;
disrupting agents;
treatment ... See more keywords