Hypothesis: By‐products of vascular disruption carried in the CSF affect prenatal brain development
Sign Up to like & getrecommendations! Published in 2022 at "Birth Defects Research"
DOI: 10.1002/bdr2.2064
Abstract: Prenatal CNS disruptions can be associated with physically separate findings. Examples include cognitive issues in septo‐optic dysplasia and sporadic and WNT1‐related unilateral cerebellar hypoplasia, and physical findings such as thinning of the corpus callosum, ventriculomegaly,… read more here.
Keywords: development; brain; disruption; hypothesis products ... See more keywords
Neuroprotection and vasculoprotection using genetically targeted protease-ligands
Sign Up to like & getrecommendations! Published in 2019 at "Brain Research"
DOI: 10.1016/j.brainres.2019.03.010
Abstract: Thrombin and activated protein C (APC) are known coagulation factors that exhibit profound effects in brain by acting on the protease activated receptor (PAR). The wild type (WT) proteases appear to impact cell survival powerfully,… read more here.
Keywords: vascular disruption; protease; vasculoprotection using; apc ... See more keywords
Embryonic vascular disruption adverse outcomes: Linking high throughput signaling signatures with functional consequences.
Sign Up to like & getrecommendations! Published in 2017 at "Reproductive toxicology"
DOI: 10.1016/j.reprotox.2017.05.005
Abstract: Embryonic vascular disruption is an important adverse outcome pathway (AOP) as chemical disruption of cardiovascular development induces broad prenatal defects. High throughput screening (HTS) assays aid AOP development although linking in vitro data to in… read more here.
Keywords: vascular disruption; disruption; disruption adverse; embryonic vascular ... See more keywords
Integrated Hydrogel Platform for Programmed Antitumor Therapy Based on Near Infrared-Triggered Hyperthermia and Vascular Disruption.
Sign Up to like & getrecommendations! Published in 2019 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.9b05536
Abstract: Complete tumor regression is a great challenge faced by single therapy of near-infrared (NIR)-triggered hyperthermia or vascular disrupting agents. An injectable nanocomposite (NC) hydrogel is rationally designed for combined anticancer therapy based on NIR-triggered hyperthermia… read more here.
Keywords: therapy based; triggered hyperthermia; hyperthermia vascular; vascular disruption ... See more keywords
Gadolinium-doped iron oxide nanoparticles induced magnetic field hyperthermia combined with radiotherapy increases tumour response by vascular disruption and improved oxygenation
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Hyperthermia"
DOI: 10.1080/02656736.2017.1308019
Abstract: Abstract The gadolinium-doped iron oxide nanoparticles (GdIONP) with greater specific power adsorption rate (SAR) than Fe3O4 was developed and its potential application in tumour therapy and particle tracking were demonstrated in transgenic adenocarcinoma of the… read more here.
Keywords: gadolinium doped; vascular disruption; hyperthermia; iron oxide ... See more keywords